tetano
Editor, Senior Moderator
J Virol
. 2023 Dec 13:e0140423.
doi: 10.1128/jvi.01404-23. Online ahead of print. Evolutionary deletions within the SARS-CoV-2 genome as signature trends for virus fitness and adaptation
Pedro Miguel Carneiro Jeronimo[SUP] 1 [/SUP], Cleber Furtado Aksenen[SUP] 1 [/SUP], Igor Oliveira Duarte[SUP] 1 [/SUP], Roberto D Lins[SUP] 2 [/SUP], Fabio Miyajima[SUP] 1 [/SUP]
Affiliations
Coronaviruses are large RNA viruses that can infect and spread among humans and animals. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019, has evolved since its first detection in December 2019. Deletions are a common occurrence in SARS-CoV-2 evolution, particularly in specific genomic sites, and may be associated with the emergence of highly competent lineages. While deletions typically have a negative impact on viral fitness, some persist and become fixed in viral populations, indicating that they may confer advantageous benefits for the virus's adaptive evolution. This work presents a literature review and data analysis on structural losses in the SARS-CoV-2 genome and the potential relevance of specific signatures for enhanced viral fitness and spread.
Keywords: SARS-CoV-2; deletions; evolutionary mechanisms; structural mutations; viral adaptation.
. 2023 Dec 13:e0140423.
doi: 10.1128/jvi.01404-23. Online ahead of print. Evolutionary deletions within the SARS-CoV-2 genome as signature trends for virus fitness and adaptation
Pedro Miguel Carneiro Jeronimo[SUP] 1 [/SUP], Cleber Furtado Aksenen[SUP] 1 [/SUP], Igor Oliveira Duarte[SUP] 1 [/SUP], Roberto D Lins[SUP] 2 [/SUP], Fabio Miyajima[SUP] 1 [/SUP]
Affiliations
- PMID: 38088350
- DOI: 10.1128/jvi.01404-23
Coronaviruses are large RNA viruses that can infect and spread among humans and animals. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019, has evolved since its first detection in December 2019. Deletions are a common occurrence in SARS-CoV-2 evolution, particularly in specific genomic sites, and may be associated with the emergence of highly competent lineages. While deletions typically have a negative impact on viral fitness, some persist and become fixed in viral populations, indicating that they may confer advantageous benefits for the virus's adaptive evolution. This work presents a literature review and data analysis on structural losses in the SARS-CoV-2 genome and the potential relevance of specific signatures for enhanced viral fitness and spread.
Keywords: SARS-CoV-2; deletions; evolutionary mechanisms; structural mutations; viral adaptation.