Giuseppe
Emeritus
[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 May 12. [Epub ahead of print]
Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China.
Huang K, Bahl J, Fan XH, Vijaykrishna D, Cheung CL, Webby RJ, Webster RG, Chen H, Smith GJ, Peiris JS, Guan Y. - International Institute of Infection and Immunity, Shantou University Medical College, Shantou 515031, Guangdong, China; State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pok Fu Lam, Hong Kong SAR, China; Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA.
Multiple reassortment events between different subtypes of endemic avian influenza viruses have increased the genomic diversity of influenza viruses circulating in poultry in southern China. Gene exchange from the natural gene pool to poultry has contributed to this increase in genetic diversity. However, the role of domestic ducks as an interface between the natural gene pool and terrestrial poultry in the influenza ecosystem has not been fully characterized. Here we phylogenetically and antigenically analyzed 170 H6 viruses isolated from domestic ducks from 2000 to 2005 in southern China which contains the largest population of domestic ducks in the world. Three distinct hemagglutinin lineages were identified. Group I contained the majority of isolates with a single internal gene complex and was endemic in domestic ducks in Guangdong since the late 1990's. Group II was derived from reassortment events in which the surface genes of Group I viruses were replaced with novel H6 and N2 genes. Group III represented H6 v viruses that undergo frequent reassortment with multiple virus subtypes from the natural gene pool. Surprisingly, H6 viruses endemic in domestic ducks and terrestrial poultry seldom reassort, but gene exchanges between viruses from domestic duck and migratory duck occurred throughout the surveillance period. These findings suggest that domestic duck in southern China mediate the interaction of viruses between different gene pools and facilitate the generation of novel influenza variants circulating in poultry.
PMID: 20463062 [PubMed - as supplied by publisher]
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J Virol. 2010 May 12. [Epub ahead of print]
Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China.
Huang K, Bahl J, Fan XH, Vijaykrishna D, Cheung CL, Webby RJ, Webster RG, Chen H, Smith GJ, Peiris JS, Guan Y. - International Institute of Infection and Immunity, Shantou University Medical College, Shantou 515031, Guangdong, China; State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pok Fu Lam, Hong Kong SAR, China; Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA.
Multiple reassortment events between different subtypes of endemic avian influenza viruses have increased the genomic diversity of influenza viruses circulating in poultry in southern China. Gene exchange from the natural gene pool to poultry has contributed to this increase in genetic diversity. However, the role of domestic ducks as an interface between the natural gene pool and terrestrial poultry in the influenza ecosystem has not been fully characterized. Here we phylogenetically and antigenically analyzed 170 H6 viruses isolated from domestic ducks from 2000 to 2005 in southern China which contains the largest population of domestic ducks in the world. Three distinct hemagglutinin lineages were identified. Group I contained the majority of isolates with a single internal gene complex and was endemic in domestic ducks in Guangdong since the late 1990's. Group II was derived from reassortment events in which the surface genes of Group I viruses were replaced with novel H6 and N2 genes. Group III represented H6 v viruses that undergo frequent reassortment with multiple virus subtypes from the natural gene pool. Surprisingly, H6 viruses endemic in domestic ducks and terrestrial poultry seldom reassort, but gene exchanges between viruses from domestic duck and migratory duck occurred throughout the surveillance period. These findings suggest that domestic duck in southern China mediate the interaction of viruses between different gene pools and facilitate the generation of novel influenza variants circulating in poultry.
PMID: 20463062 [PubMed - as supplied by publisher]
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