Giuseppe
Emeritus
Assessment Of Seasonal Influenza A Specific CD4 T Cell Responses To 2009 Pandemic H1N1 Swine-Origin Influenza A Virus. (J Virol., abstract, edited)
J Virol. 2010 Jan 13. [Epub ahead of print]
Assessment Of Seasonal Influenza A Specific CD4 T Cell Responses To 2009 Pandemic H1N1 Swine-Origin Influenza A Virus.
Ge X, Tan V, Bollyky PL, Standifer NE, James EA, Kwok WW. - Benaroya Research Institute at Virginia Mason, Seattle, Washington.
Very limited evidence has been reported to show human adaptive immune responses to the 2009 pandemic H1N1 swine-origin influenza A virus (S-OIV). We studied 17 S-OIV peptides homologous to immunodominant CD4 T epitopes from HA, NA, NP, MP and PB1 of a seasonal H1N1 strain. We concluded that 15 of these 17 S-OIV peptides would induce responses of seasonal influenza-specific T cells. Of these, 7 S-OIV sequences were identical to seasonal influenza sequences while 8 had at least one amino acid that was not conserved. T cells recognizing epitopes derived from these S-OIV antigens could be detected ex vivo. Most of these T cells expressed memory markers, although none of the donors had been exposed to S-OIV. Functional analysis revealed that specific amino acid differences in the sequences of these S-OIV peptides would not affect or partially affect memory T cell responses. These findings suggest that without protective antibody responses, seasonal influenza A vaccinated individuals may still benefit from pre-existing cross-reactive memory CD4 T cells reducing their susceptibility to S-OIV infection.
PMID: 20071564 [PubMed - as supplied by publisher]
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J Virol. 2010 Jan 13. [Epub ahead of print]
Assessment Of Seasonal Influenza A Specific CD4 T Cell Responses To 2009 Pandemic H1N1 Swine-Origin Influenza A Virus.
Ge X, Tan V, Bollyky PL, Standifer NE, James EA, Kwok WW. - Benaroya Research Institute at Virginia Mason, Seattle, Washington.
Very limited evidence has been reported to show human adaptive immune responses to the 2009 pandemic H1N1 swine-origin influenza A virus (S-OIV). We studied 17 S-OIV peptides homologous to immunodominant CD4 T epitopes from HA, NA, NP, MP and PB1 of a seasonal H1N1 strain. We concluded that 15 of these 17 S-OIV peptides would induce responses of seasonal influenza-specific T cells. Of these, 7 S-OIV sequences were identical to seasonal influenza sequences while 8 had at least one amino acid that was not conserved. T cells recognizing epitopes derived from these S-OIV antigens could be detected ex vivo. Most of these T cells expressed memory markers, although none of the donors had been exposed to S-OIV. Functional analysis revealed that specific amino acid differences in the sequences of these S-OIV peptides would not affect or partially affect memory T cell responses. These findings suggest that without protective antibody responses, seasonal influenza A vaccinated individuals may still benefit from pre-existing cross-reactive memory CD4 T cells reducing their susceptibility to S-OIV infection.
PMID: 20071564 [PubMed - as supplied by publisher]
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