Giuseppe
Emeritus
[Source: Journal of Virology, full page: (LINK). Abstract, edited.]
Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites
Zhimin Wan a,b, Jianqiang Ye a,b, Liangliang Xu a,b, Hongxia Shao a,b, Wenjie Jin a,b, Kun Qian a,b, Hongquan Wan a,b** and Aijian Qin a,b**
Author Affiliations: <SUP>a</SUP>College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China <SUP>b</SUP>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China
ABSTRACT
H9N2 influenza virus is undergoing extensive genetic and antigenic evolution, warranting detail antigenic mapping of its hemagglutinin (HA). Through examining antibody escape mutants of an Asian avian H9N2 virus, we identified 9 critical amino acid positions in H9 antigenic sites. Five of these positions, 164, 167, 168, 196 and 207, have not been reported previously, representing novel molecular markers for monitoring the antigenic change of H9N2 virus.
FOOTNOTES
**Corresponse to: Hongquan Wan, DVM, PhD, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China, Email: hqwan129@yahoo.com
**Aijian Qin, DVM, PhD, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China, E-mail: aijian@yzu.edu.cn, Tel: +86 0514 87979217 Fax: +86 0514 87979217
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
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Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites
Zhimin Wan a,b, Jianqiang Ye a,b, Liangliang Xu a,b, Hongxia Shao a,b, Wenjie Jin a,b, Kun Qian a,b, Hongquan Wan a,b** and Aijian Qin a,b**
Author Affiliations: <SUP>a</SUP>College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China <SUP>b</SUP>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China
ABSTRACT
H9N2 influenza virus is undergoing extensive genetic and antigenic evolution, warranting detail antigenic mapping of its hemagglutinin (HA). Through examining antibody escape mutants of an Asian avian H9N2 virus, we identified 9 critical amino acid positions in H9 antigenic sites. Five of these positions, 164, 167, 168, 196 and 207, have not been reported previously, representing novel molecular markers for monitoring the antigenic change of H9N2 virus.
FOOTNOTES
**Corresponse to: Hongquan Wan, DVM, PhD, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China, Email: hqwan129@yahoo.com
**Aijian Qin, DVM, PhD, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China, E-mail: aijian@yzu.edu.cn, Tel: +86 0514 87979217 Fax: +86 0514 87979217
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
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