tetano
Editor, Senior Moderator
J Trop Pediatr
. 2021 Dec 8;67(6):fmab104.
doi: 10.1093/tropej/fmab104.
A Comparative Study of Children with MIS-C between Admitted to the Pediatric Intensive Care Unit and Pediatric Ward: A One-Year Retrospective Study
Elif Kıymet[SUP] 1 [/SUP], Elif Böncüoğlu[SUP] 1 [/SUP], Şahika Şahinkaya[SUP] 1 [/SUP], Ela Cem[SUP] 1 [/SUP], Miray Yılmaz Çelebi[SUP] 1 [/SUP], Mine Düzgöl[SUP] 1 [/SUP], Aybüke Akaslan Kara[SUP] 1 [/SUP], Kamile Ötiken Arıkan[SUP] 1 [/SUP], Gamze Talay Vuran[SUP] 2 [/SUP], Murat Muhtar Yılmazer[SUP] 2 [/SUP], Özlem Saraç Sandal[SUP] 3 [/SUP], Hasan Ağın[SUP] 3 [/SUP], Neslihan Pirinç[SUP] 4 [/SUP], Nuri Bayram[SUP] 1 [/SUP], İlker Devrim[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: This descriptive study aimed to compare the clinical and laboratory features of the children with the multisystem inflammatory syndrome in children (MIS-C), requiring pediatric intensive care unit (PICU), admission with the MIS-C patients who did not require PICU admission.
Patients and methods: This study was conducted between March 2020 and February 2021 at the University of Health Sciences Dr. Behçet Uz Children's Hospital, a referral center for pediatric infectious diseases in the Aegean Region of Turkey. All hospitalized patients aged 18 years old or less with MIS-C according to the definition of the universal guidelines were included in the study. Data of the patients with the diagnosis of MIS-C were recorded and collected from the electronic medical records of the hospital. The data included demographic characteristics, presenting signs and symptoms, laboratory findings and clinical data.
Results: A total of 58 patients with MIS-C were included in this study. Thirty-eight (65.5%) patients were male. The median age was 6 years (2 months-16 years). The patients admitted to PICU were 15 (25.9%). The rate of pulmonary involvement was 81.3% (n = 13) in the PICU group. The median procalcitonin, C-reactive protein, erythrocyte sedimentation rate, D-Dimer and ferritin values were significantly higher in the PICU group compared to non-PICU group (p < 0.001, p = 0.02, p < 0.001, p = 0.006 and p = 0.031).
Conclusions: Besides the depressing cardiac functions reported before, the pulmonary involvement and signs of shock are important factors for PICU admission in children with MIS-C.
Keywords: coronavirus disease 2019 (COVID-19); multisystem inflammatory syndrome in children (MIS-C); pediatric intensive care unit (PICU); pulmonary involvement; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2021 Dec 8;67(6):fmab104.
doi: 10.1093/tropej/fmab104.
A Comparative Study of Children with MIS-C between Admitted to the Pediatric Intensive Care Unit and Pediatric Ward: A One-Year Retrospective Study
Elif Kıymet[SUP] 1 [/SUP], Elif Böncüoğlu[SUP] 1 [/SUP], Şahika Şahinkaya[SUP] 1 [/SUP], Ela Cem[SUP] 1 [/SUP], Miray Yılmaz Çelebi[SUP] 1 [/SUP], Mine Düzgöl[SUP] 1 [/SUP], Aybüke Akaslan Kara[SUP] 1 [/SUP], Kamile Ötiken Arıkan[SUP] 1 [/SUP], Gamze Talay Vuran[SUP] 2 [/SUP], Murat Muhtar Yılmazer[SUP] 2 [/SUP], Özlem Saraç Sandal[SUP] 3 [/SUP], Hasan Ağın[SUP] 3 [/SUP], Neslihan Pirinç[SUP] 4 [/SUP], Nuri Bayram[SUP] 1 [/SUP], İlker Devrim[SUP] 1 [/SUP]
Affiliations
- PMID: 34931251
- DOI: 10.1093/tropej/fmab104
Abstract
Objectives: This descriptive study aimed to compare the clinical and laboratory features of the children with the multisystem inflammatory syndrome in children (MIS-C), requiring pediatric intensive care unit (PICU), admission with the MIS-C patients who did not require PICU admission.
Patients and methods: This study was conducted between March 2020 and February 2021 at the University of Health Sciences Dr. Behçet Uz Children's Hospital, a referral center for pediatric infectious diseases in the Aegean Region of Turkey. All hospitalized patients aged 18 years old or less with MIS-C according to the definition of the universal guidelines were included in the study. Data of the patients with the diagnosis of MIS-C were recorded and collected from the electronic medical records of the hospital. The data included demographic characteristics, presenting signs and symptoms, laboratory findings and clinical data.
Results: A total of 58 patients with MIS-C were included in this study. Thirty-eight (65.5%) patients were male. The median age was 6 years (2 months-16 years). The patients admitted to PICU were 15 (25.9%). The rate of pulmonary involvement was 81.3% (n = 13) in the PICU group. The median procalcitonin, C-reactive protein, erythrocyte sedimentation rate, D-Dimer and ferritin values were significantly higher in the PICU group compared to non-PICU group (p < 0.001, p = 0.02, p < 0.001, p = 0.006 and p = 0.031).
Conclusions: Besides the depressing cardiac functions reported before, the pulmonary involvement and signs of shock are important factors for PICU admission in children with MIS-C.
Keywords: coronavirus disease 2019 (COVID-19); multisystem inflammatory syndrome in children (MIS-C); pediatric intensive care unit (PICU); pulmonary involvement; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).