tetano
Editor, Senior Moderator
J Thromb Haemost
. 2020 Jul 21.
doi: 10.1111/jth.15021. Online ahead of print.
Multifactorial pathogenesis of COVID-19-related coagulopathy. Can defibrotide have a role in the early phases of coagulation disorders?
Antonio Macci?[SUP] 1 [/SUP], Clelia Madeddu[SUP] 2 [/SUP], Giovanni Caocci[SUP] 3 [/SUP], Giorgio La Nasa[SUP] 3 [/SUP]
Affiliations
Abstract
Thrombotic complications emerged as an important issue in patients with coronavirus disease 2019 (COVID-19). Consolidated reports regarding the clinical and laboratory findings in COVID-19 patients reveal thrombocytopenia, elevated D-dimer, prolonged prothrombin time, disseminated intravascular coagulation, and pulmonary intravascular coagulation (PIC). Recently, some authors emphasized the potential role of antiphospholipid antibodies in the pathogenesis of thrombotic events in patients with severe COVID-19.
Keywords: COVID-19; defibrotide; inflammation; macrophages; oxidative stress; pulmonary intravascular coagulation.
. 2020 Jul 21.
doi: 10.1111/jth.15021. Online ahead of print.
Multifactorial pathogenesis of COVID-19-related coagulopathy. Can defibrotide have a role in the early phases of coagulation disorders?
Antonio Macci?[SUP] 1 [/SUP], Clelia Madeddu[SUP] 2 [/SUP], Giovanni Caocci[SUP] 3 [/SUP], Giorgio La Nasa[SUP] 3 [/SUP]
Affiliations
- PMID: 32692894
- DOI: 10.1111/jth.15021
Abstract
Thrombotic complications emerged as an important issue in patients with coronavirus disease 2019 (COVID-19). Consolidated reports regarding the clinical and laboratory findings in COVID-19 patients reveal thrombocytopenia, elevated D-dimer, prolonged prothrombin time, disseminated intravascular coagulation, and pulmonary intravascular coagulation (PIC). Recently, some authors emphasized the potential role of antiphospholipid antibodies in the pathogenesis of thrombotic events in patients with severe COVID-19.
Keywords: COVID-19; defibrotide; inflammation; macrophages; oxidative stress; pulmonary intravascular coagulation.