tetano
Editor, Senior Moderator
J Thromb Haemost
. 2020 May 28.
doi: 10.1111/jth.14938. Online ahead of print.
Macrothrombosis and Stroke in Patients With Mild Covid-19 Infection
Michael G Fara[SUP] 1 [/SUP], Laura K Stein[SUP] 1 [/SUP], Maryna Skliut[SUP] 1 [/SUP], Susan Morgello[SUP] 1 2 [/SUP], Johanna T Fifi[SUP] 3 [/SUP], Mandip S Dhamoon[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic disease currently affecting millions of people worldwide. Its neurological implications are poorly understood, and further study is urgently required. A hypercoagulable state has been reported in patients with severe COVID-19, but nothing is known about coagulopathy in patients with milder disease. We describe cases of patients in New York City presenting with stroke secondary to large vessel thrombosis without occlusion, incidentally found to have COVID-19 with only mild respiratory symptoms. This is in contrast to the venous thrombosis and microangiopathy that has been reported in patients with severe COVID-19. Our cases suggest that even in the absence of severe disease, patients with COVID-19 may be at increased risk of thrombus formation leading to stroke, perhaps due to viral involvement of the endothelium. Further systematic study is needed, since this may have implications for primary and secondary stroke prevention in patients with COVID-19.
Keywords: Carotid Artery Thrombosis; Coronavirus; Infection; Stroke; Thrombosis
. 2020 May 28.
doi: 10.1111/jth.14938. Online ahead of print.
Macrothrombosis and Stroke in Patients With Mild Covid-19 Infection
Michael G Fara[SUP] 1 [/SUP], Laura K Stein[SUP] 1 [/SUP], Maryna Skliut[SUP] 1 [/SUP], Susan Morgello[SUP] 1 2 [/SUP], Johanna T Fifi[SUP] 3 [/SUP], Mandip S Dhamoon[SUP] 1 [/SUP]
Affiliations
- PMID: 32464707
- DOI: 10.1111/jth.14938
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic disease currently affecting millions of people worldwide. Its neurological implications are poorly understood, and further study is urgently required. A hypercoagulable state has been reported in patients with severe COVID-19, but nothing is known about coagulopathy in patients with milder disease. We describe cases of patients in New York City presenting with stroke secondary to large vessel thrombosis without occlusion, incidentally found to have COVID-19 with only mild respiratory symptoms. This is in contrast to the venous thrombosis and microangiopathy that has been reported in patients with severe COVID-19. Our cases suggest that even in the absence of severe disease, patients with COVID-19 may be at increased risk of thrombus formation leading to stroke, perhaps due to viral involvement of the endothelium. Further systematic study is needed, since this may have implications for primary and secondary stroke prevention in patients with COVID-19.
Keywords: Carotid Artery Thrombosis; Coronavirus; Infection; Stroke; Thrombosis