tetano
Editor, Senior Moderator
J Thorac Oncol. 2020 Feb 27. pii: S1556-0864(20)30132-5. doi: 10.1016/j.jtho.2020.02.010. [Epub ahead of print] [h=1]Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer.[/h]
Tian S[SUP]1[/SUP], Hu W[SUP]2[/SUP], Niu L[SUP]1[/SUP], Liu H[SUP]1[/SUP], Xu H[SUP]3[/SUP], Xiao SY[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.
Copyright ? 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] COVID-19 pneumonia; SARS-CoV-2; coronavirus; pathology
PMID: 32114094 DOI: 10.1016/j.jtho.2020.02.010
Tian S[SUP]1[/SUP], Hu W[SUP]2[/SUP], Niu L[SUP]1[/SUP], Liu H[SUP]1[/SUP], Xu H[SUP]3[/SUP], Xiao SY[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.
Copyright ? 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] COVID-19 pneumonia; SARS-CoV-2; coronavirus; pathology
PMID: 32114094 DOI: 10.1016/j.jtho.2020.02.010
