tetano
Editor, Senior Moderator
J Thorac Imaging. 2020 Apr 28. doi: 10.1097/RTI.0000000000000530. [Epub ahead of print]
Is COVID Evolution Due to Occurrence of Pulmonary Vascular Thrombosis?
Saba L[SUP]1[/SUP], Sverzellati N[SUP]2[/SUP].
Author information
Abstract
In this hypothesis paper, we suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce intravascular pulmonary thrombosis, which may result in the rapid worsening of clinical conditions and, eventually, exitus. Previously published papers have demonstrated that increased levels of D-dimer at hospital admission correlate with a more severe disease (0.5 mg/L) or occurrence of death (1 mg/L). The potential prothrombotic action of the SARS-CoV-2 is supported by the topographical involvement of the lung regions with a predilection for the lower lobe with peripheral involvement. If this hypothesis is demonstrated, this could suggest the benefit of using antithrombotic/coagulation regimens for SARS-CoV-2 and, at the same time, the urgency to identify drugs that could alter the inflammatory storm, thus protecting the vessel wall.
PMID:32349055DOI:10.1097/RTI.0000000000000530
Is COVID Evolution Due to Occurrence of Pulmonary Vascular Thrombosis?
Saba L[SUP]1[/SUP], Sverzellati N[SUP]2[/SUP].
Author information
Abstract
In this hypothesis paper, we suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce intravascular pulmonary thrombosis, which may result in the rapid worsening of clinical conditions and, eventually, exitus. Previously published papers have demonstrated that increased levels of D-dimer at hospital admission correlate with a more severe disease (0.5 mg/L) or occurrence of death (1 mg/L). The potential prothrombotic action of the SARS-CoV-2 is supported by the topographical involvement of the lung regions with a predilection for the lower lobe with peripheral involvement. If this hypothesis is demonstrated, this could suggest the benefit of using antithrombotic/coagulation regimens for SARS-CoV-2 and, at the same time, the urgency to identify drugs that could alter the inflammatory storm, thus protecting the vessel wall.
PMID:32349055DOI:10.1097/RTI.0000000000000530