tetano
Editor, Senior Moderator
J Stroke Cerebrovasc Dis
. 2020 Dec 15;30(3):105549.
doi: 10.1016/j.jstrokecerebrovasdis.2020.105549. Online ahead of print.
Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors
Isabel Siow[SUP] 1 [/SUP], Keng Siang Lee[SUP] 2 [/SUP], John J Y Zhang[SUP] 3 [/SUP], Seyed Ehsan Saffari[SUP] 4 [/SUP], Adeline Ng[SUP] 5 [/SUP], Barnaby Young[SUP] 6 [/SUP]
Affiliations
Abstract
Introduction: COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19.
Methods: We conducted a systematic review of all studies published between November 1, 2019 and July 8, 2020 which reported on patients who suffered from stroke as a complication of COVID-19.
Results: 326 studies were screened, and 30 studies reporting findings from 55,176 patients including 899 with stroke were included. The average age of patients who suffered from stroke as a complication of COVID-19 was 65.5 (Range: 40.4-76.4 years). The average incidence of stroke as a complication of COVID-19 was 1.74% (95% CI: 1.09% to 2.51%). The average mortality of stroke in COVID-19 patients was 31.76% (95% CI: 17.77% to 47.31%). These patients also had deranged clinical parameters including deranged coagulation profiles, liver function tests, and full blood counts.
Conclusion: Although stroke is an uncommon complication of COVID-19, when present, it often results in significant morbidity and mortality. In COVID-19 patients, stroke was associated with older age, comorbidities, and severe illness.
Keywords: COVID-19; Cerebrovascular accident; Complication; Coronavirus; Stroke.
. 2020 Dec 15;30(3):105549.
doi: 10.1016/j.jstrokecerebrovasdis.2020.105549. Online ahead of print.
Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors
Isabel Siow[SUP] 1 [/SUP], Keng Siang Lee[SUP] 2 [/SUP], John J Y Zhang[SUP] 3 [/SUP], Seyed Ehsan Saffari[SUP] 4 [/SUP], Adeline Ng[SUP] 5 [/SUP], Barnaby Young[SUP] 6 [/SUP]
Affiliations
- PMID: 33341565
- DOI: 10.1016/j.jstrokecerebrovasdis.2020.105549
Abstract
Introduction: COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19.
Methods: We conducted a systematic review of all studies published between November 1, 2019 and July 8, 2020 which reported on patients who suffered from stroke as a complication of COVID-19.
Results: 326 studies were screened, and 30 studies reporting findings from 55,176 patients including 899 with stroke were included. The average age of patients who suffered from stroke as a complication of COVID-19 was 65.5 (Range: 40.4-76.4 years). The average incidence of stroke as a complication of COVID-19 was 1.74% (95% CI: 1.09% to 2.51%). The average mortality of stroke in COVID-19 patients was 31.76% (95% CI: 17.77% to 47.31%). These patients also had deranged clinical parameters including deranged coagulation profiles, liver function tests, and full blood counts.
Conclusion: Although stroke is an uncommon complication of COVID-19, when present, it often results in significant morbidity and mortality. In COVID-19 patients, stroke was associated with older age, comorbidities, and severe illness.
Keywords: COVID-19; Cerebrovascular accident; Complication; Coronavirus; Stroke.