tetano
Editor, Senior Moderator
J Stroke Cerebrovasc Dis
. 2022 Nov 22;32(1):106903.
doi: 10.1016/j.jstrokecerebrovasdis.2022.106903. Online ahead of print.
COVID-19 independently predicts poor outcomes in Acute Ischemic Stroke- Insights from a multicenter study from Pakistan and United Arab Emirates
Maria Khan[SUP] 1 [/SUP], Sajid Hameed[SUP] 2 [/SUP], Bashir A Soomro[SUP] 3 [/SUP], Samar Mairaj[SUP] 4 [/SUP], Abdul Malik[SUP] 5 [/SUP], Saba Farooq[SUP] 1 [/SUP], Suhail Al Rukn[SUP] 1 [/SUP], Mohammad Wasay[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Ischemic stroke associated with coronavirus 2019 (COVID-19) has been well recognized by now. Few studies have compared COVID related versus unrelated strokes. We intend to report on a large group of Asian patients from two countries and compare COVID with non-COVID strokes admitted during the same time period.
Methods: Consecutive cases of acute ischemic stroke either presenting or developing, between March 2020 and December 2021 in four tertiary care hospitals (1 in Dubai, UAE and 3 in Karachi, Pakistan) and testing positive for COVID-19 were included in the study. Patients admitted with ischemic stroke during the same time period and who tested negative for COVID-19 were also randomly selected from the four hospitals. All data was collected from the medical records of the patients and recorded on a standard questionnaire before it was entered in SPSS version 21 for analysis.
Results: There were 139 COVID positive and 271 COVID negative patients with acute ischemic stroke included in the current study. There were significantly more males (80.6% vs 64.9%, p=0.001) and more large vessel strokes in the COVID positive group (41% vs 21.8%, p<0.001). Being COVID positive was an independent predictor of poor outcome at discharge, defined as a modified Rankin score of 3-6 (OR 3.87, 95% CI 2.21-6.77) after adjusting for country, age, sex, vascular comorbid conditions and stroke subtype.
Conclusions: In this largest series of patients with COVID related strokes from Asia, COVID-19 was an independent predictor of poor outcomes at discharge after adjusting for other variables.
Keywords: COVID-19; Functional outcomes; Ischemic stroke; Mortality.
. 2022 Nov 22;32(1):106903.
doi: 10.1016/j.jstrokecerebrovasdis.2022.106903. Online ahead of print.
COVID-19 independently predicts poor outcomes in Acute Ischemic Stroke- Insights from a multicenter study from Pakistan and United Arab Emirates
Maria Khan[SUP] 1 [/SUP], Sajid Hameed[SUP] 2 [/SUP], Bashir A Soomro[SUP] 3 [/SUP], Samar Mairaj[SUP] 4 [/SUP], Abdul Malik[SUP] 5 [/SUP], Saba Farooq[SUP] 1 [/SUP], Suhail Al Rukn[SUP] 1 [/SUP], Mohammad Wasay[SUP] 6 [/SUP]
Affiliations
- PMID: 36436361
- DOI: 10.1016/j.jstrokecerebrovasdis.2022.106903
Abstract
Background: Ischemic stroke associated with coronavirus 2019 (COVID-19) has been well recognized by now. Few studies have compared COVID related versus unrelated strokes. We intend to report on a large group of Asian patients from two countries and compare COVID with non-COVID strokes admitted during the same time period.
Methods: Consecutive cases of acute ischemic stroke either presenting or developing, between March 2020 and December 2021 in four tertiary care hospitals (1 in Dubai, UAE and 3 in Karachi, Pakistan) and testing positive for COVID-19 were included in the study. Patients admitted with ischemic stroke during the same time period and who tested negative for COVID-19 were also randomly selected from the four hospitals. All data was collected from the medical records of the patients and recorded on a standard questionnaire before it was entered in SPSS version 21 for analysis.
Results: There were 139 COVID positive and 271 COVID negative patients with acute ischemic stroke included in the current study. There were significantly more males (80.6% vs 64.9%, p=0.001) and more large vessel strokes in the COVID positive group (41% vs 21.8%, p<0.001). Being COVID positive was an independent predictor of poor outcome at discharge, defined as a modified Rankin score of 3-6 (OR 3.87, 95% CI 2.21-6.77) after adjusting for country, age, sex, vascular comorbid conditions and stroke subtype.
Conclusions: In this largest series of patients with COVID related strokes from Asia, COVID-19 was an independent predictor of poor outcomes at discharge after adjusting for other variables.
Keywords: COVID-19; Functional outcomes; Ischemic stroke; Mortality.