tetano
Editor, Senior Moderator
J Reprod Immunol. 2020 Mar 19;139:103122. doi: 10.1016/j.jri.2020.103122. [Epub ahead of print]
Why are pregnant women susceptible to COVID-19? An immunological viewpoint.
Liu H[SUP]1[/SUP], Wang LL[SUP]1[/SUP], Zhao SJ[SUP]1[/SUP], Kwak-Kim J[SUP]2[/SUP], Mor G[SUP]3[/SUP], Liao AH[SUP]4[/SUP].
Author information
Abstract
The 2019 novel coronavirus disease (COVID-19) was first detected in December 2019 and became epidemic in Wuhan, Hubei Province, China. COVID-19 has been rapidly spreading out in China and all over the world. The virus causing COVID-19, SARS-CoV-2 has been known to be genetically similar to severe acute respiratory syndrome coronavirus (SARS-CoV) but distinct from it. Clinical manifestation of COVID-19 can be characterized by mild upper respiratory tract infection, lower respiratory tract infection involving non-life threatening pneumonia, and life-threatening pneumonia with acute respiratory distress syndrome. It affects all age groups, including newborns, to the elders. Particularly, pregnant women may be more susceptible to COVID-19 since pregnant women, in general, are vulnerable to respiratory infection. In pregnant women with COVID-19, there is no evidence for vertical transmission of the virus, but an increased prevalence of preterm deliveries has been noticed. The COVID-19 may alter immune responses at the maternal-fetal interface, and affect the well-being of mothers and infants. In this review, we focused on the reason why pregnant women are more susceptible to COVID-19 and the potential maternal and fetal complications from an immunological viewpoint.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
COVID-19; Immunity; Maternal-fetal interface; Placenta; Pregnancy
PMID:32244166DOI:10.1016/j.jri.2020.103122
Why are pregnant women susceptible to COVID-19? An immunological viewpoint.
Liu H[SUP]1[/SUP], Wang LL[SUP]1[/SUP], Zhao SJ[SUP]1[/SUP], Kwak-Kim J[SUP]2[/SUP], Mor G[SUP]3[/SUP], Liao AH[SUP]4[/SUP].
Author information
Abstract
The 2019 novel coronavirus disease (COVID-19) was first detected in December 2019 and became epidemic in Wuhan, Hubei Province, China. COVID-19 has been rapidly spreading out in China and all over the world. The virus causing COVID-19, SARS-CoV-2 has been known to be genetically similar to severe acute respiratory syndrome coronavirus (SARS-CoV) but distinct from it. Clinical manifestation of COVID-19 can be characterized by mild upper respiratory tract infection, lower respiratory tract infection involving non-life threatening pneumonia, and life-threatening pneumonia with acute respiratory distress syndrome. It affects all age groups, including newborns, to the elders. Particularly, pregnant women may be more susceptible to COVID-19 since pregnant women, in general, are vulnerable to respiratory infection. In pregnant women with COVID-19, there is no evidence for vertical transmission of the virus, but an increased prevalence of preterm deliveries has been noticed. The COVID-19 may alter immune responses at the maternal-fetal interface, and affect the well-being of mothers and infants. In this review, we focused on the reason why pregnant women are more susceptible to COVID-19 and the potential maternal and fetal complications from an immunological viewpoint.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
COVID-19; Immunity; Maternal-fetal interface; Placenta; Pregnancy
PMID:32244166DOI:10.1016/j.jri.2020.103122