tetano
Editor, Senior Moderator
J Proteome Res
. 2022 Feb 10.
doi: 10.1021/acs.jproteome.2c00001. Online ahead of print.
Computational, Experimental, and Clinical Evidence of a Specific but Peculiar Evolutionary Nature of (COVID-19) SARS-CoV-2
Gerard Kian-Meng Goh[SUP] 1 [/SUP], A Keith Dunker[SUP] 2 [/SUP], James A Foster[SUP] 3 4 [/SUP], Vladimir N Uversky[SUP] 5 6 [/SUP]
Affiliations
Abstract
The shell disorder models have predicted that SARS-CoV-2 is of a specific but peculiar evolutionary nature. All coronaviruses (CoVs) closely related to SARS-CoV-2 have been found to have the hardest outer shells (M protein) among CoVs. This hard shell (low M percentage of intrinsic disorder (PID)) is associated with burrowing animals, for example, pangolins, and is believed to be responsible for the high contagiousness of SARS-CoV-2 because it will be more resistant to antimicrobial enzymes found in saliva/mucus. Incoming clinical and experimental data do support this along with a prediction based on another aspect of the shell (N, inner shell) disorder models that SARS-CoV-1 is more virulent than SARS-CoV-2 because SARS-CoV-2 produces fewer virus copies in vital organs even if large amounts of infections particles are shed orally and nasally. A phylogenetic study using M reveals a closer relationship of SARS-CoV to pangolin-CoVs than the bat-RaTG13 found in Yunnan, China. Previous studies may have been confused by recombinations that were poorly handled. The shell disorder models suggest that a pangolin-CoV strain may have entered the human population in 2017 or before as an attenuated virus, which could explain why SARS-CoV is found to be highly adapted to humans.
Keywords: COVID; antibody; attenuate; coronavirus; disorder; immune; intrinsic; matrix; membrane; nucleocapsid; nucleoprotein; omicron; pangolin; protein; severe acute respiratory; shell; vaccine; virulence.
. 2022 Feb 10.
doi: 10.1021/acs.jproteome.2c00001. Online ahead of print.
Computational, Experimental, and Clinical Evidence of a Specific but Peculiar Evolutionary Nature of (COVID-19) SARS-CoV-2
Gerard Kian-Meng Goh[SUP] 1 [/SUP], A Keith Dunker[SUP] 2 [/SUP], James A Foster[SUP] 3 4 [/SUP], Vladimir N Uversky[SUP] 5 6 [/SUP]
Affiliations
- PMID: 35142523
- DOI: 10.1021/acs.jproteome.2c00001
Abstract
The shell disorder models have predicted that SARS-CoV-2 is of a specific but peculiar evolutionary nature. All coronaviruses (CoVs) closely related to SARS-CoV-2 have been found to have the hardest outer shells (M protein) among CoVs. This hard shell (low M percentage of intrinsic disorder (PID)) is associated with burrowing animals, for example, pangolins, and is believed to be responsible for the high contagiousness of SARS-CoV-2 because it will be more resistant to antimicrobial enzymes found in saliva/mucus. Incoming clinical and experimental data do support this along with a prediction based on another aspect of the shell (N, inner shell) disorder models that SARS-CoV-1 is more virulent than SARS-CoV-2 because SARS-CoV-2 produces fewer virus copies in vital organs even if large amounts of infections particles are shed orally and nasally. A phylogenetic study using M reveals a closer relationship of SARS-CoV to pangolin-CoVs than the bat-RaTG13 found in Yunnan, China. Previous studies may have been confused by recombinations that were poorly handled. The shell disorder models suggest that a pangolin-CoV strain may have entered the human population in 2017 or before as an attenuated virus, which could explain why SARS-CoV is found to be highly adapted to humans.
Keywords: COVID; antibody; attenuate; coronavirus; disorder; immune; intrinsic; matrix; membrane; nucleocapsid; nucleoprotein; omicron; pangolin; protein; severe acute respiratory; shell; vaccine; virulence.