tetano
Editor, Senior Moderator
J Pharm Investig
. 2021 Mar 5;1-16.
doi: 10.1007/s40005-021-00520-4. Online ahead of print.
Potential therapeutic and pharmacological strategies for SARS-CoV2
Doaa A Ghareeb[SUP] 1 2 [/SUP], Samar R Saleh[SUP] 1 2 [/SUP], Mohammed S Nofal[SUP] 2 [/SUP], Mohamed M Y Kaddah[SUP] 2 [/SUP], Salma F Hassan[SUP] 2 [/SUP], Inas K Seif[SUP] 1 [/SUP], Sally A El-Zahaby[SUP] 3 [/SUP], Shaimaa M Khedr[SUP] 2 [/SUP], Marwa Y Kenawy[SUP] 4 [/SUP], Aliaa A Masoud[SUP] 1 [/SUP], Salma A Soudi[SUP] 2 [/SUP], Ahmed A Sobhy[SUP] 1 2 5 [/SUP], Jaillan G Sery[SUP] 2 [/SUP], Miral G Abd El-Wahab[SUP] 2 [/SUP], Alshimaa A Abd Elmoneam[SUP] 1 [/SUP], Abdulaziz Mohsen Al-Mahallawi[SUP] 6 7 [/SUP], Maha A El-Demellawy[SUP] 2 8 [/SUP]
Affiliations
Abstract
Background: At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic.
Area covered: Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti-SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of different therapeutic strategies are summarized. According to the WHO, different classes of drugs can be used, including anti-malarial, antiviral, anti-inflammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2.
Expert opinion: A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.
Supplementary information: The online version contains supplementary material available at 10.1007/s40005-021-00520-4.
Keywords: COVID-19; Camostat; Hydroxychloroquine; Indomethacin; Teicoplanin; Tocilizumab.
. 2021 Mar 5;1-16.
doi: 10.1007/s40005-021-00520-4. Online ahead of print.
Potential therapeutic and pharmacological strategies for SARS-CoV2
Doaa A Ghareeb[SUP] 1 2 [/SUP], Samar R Saleh[SUP] 1 2 [/SUP], Mohammed S Nofal[SUP] 2 [/SUP], Mohamed M Y Kaddah[SUP] 2 [/SUP], Salma F Hassan[SUP] 2 [/SUP], Inas K Seif[SUP] 1 [/SUP], Sally A El-Zahaby[SUP] 3 [/SUP], Shaimaa M Khedr[SUP] 2 [/SUP], Marwa Y Kenawy[SUP] 4 [/SUP], Aliaa A Masoud[SUP] 1 [/SUP], Salma A Soudi[SUP] 2 [/SUP], Ahmed A Sobhy[SUP] 1 2 5 [/SUP], Jaillan G Sery[SUP] 2 [/SUP], Miral G Abd El-Wahab[SUP] 2 [/SUP], Alshimaa A Abd Elmoneam[SUP] 1 [/SUP], Abdulaziz Mohsen Al-Mahallawi[SUP] 6 7 [/SUP], Maha A El-Demellawy[SUP] 2 8 [/SUP]
Affiliations
- PMID: 33688448
- PMCID: PMC7933375
- DOI: 10.1007/s40005-021-00520-4
Abstract
Background: At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic.
Area covered: Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti-SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of different therapeutic strategies are summarized. According to the WHO, different classes of drugs can be used, including anti-malarial, antiviral, anti-inflammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2.
Expert opinion: A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.
Supplementary information: The online version contains supplementary material available at 10.1007/s40005-021-00520-4.
Keywords: COVID-19; Camostat; Hydroxychloroquine; Indomethacin; Teicoplanin; Tocilizumab.