tetano
Editor, Senior Moderator
J Pharm Health Care Sci
. 2025 Oct 27;11(1):94.
doi: 10.1186/s40780-025-00501-x. Clinical efficacy of casirivimab and imdevimab in preventing COVID-19 in the Omicron BA.5 subvariant epidemic: a retrospective study
Mariko Ohtani[SUP] 1 2 [/SUP], Takuya Yokoo[SUP] 3 [/SUP], Taito Miyazaki[SUP] 4 5 [/SUP], Hiroshi Yasuda[SUP] 3 [/SUP], Eriko Nishikawa[SUP] 4 [/SUP], Manabu Tomida[SUP] 4 [/SUP], Mayumi Tsukada[SUP] 4 [/SUP], Emi Sato[SUP] 6 [/SUP], Shinobu Hirayama[SUP] 3 [/SUP], Hinako Murakami[SUP] 4 7 [/SUP], Sadako Yoshizawa[SUP] 7 8 [/SUP], Takahiro Matsumoto[SUP] 3 [/SUP], Kazuhiro Tateda[SUP] 4 7 8 [/SUP]
Affiliations
Background: The neutralizing monoclonal antibody combination of casirivimab and imdevimab (CAS + IMD) is the only therapy approved for preventing coronavirus disease 2019 (COVID-19) following exposure to severe acute respiratory syndrome coronavirus 2. However, the efficacy of CAS + IMD against Omicron variants remains uncertain, with in vitro studies indicating reduced neutralizing activity. This study aimed to evaluate the clinical efficacy of CAS + IMD in preventing COVID-19 among uninfected hospitalized contacts of patients with COVID-19.
Methods: A retrospective chart review was conducted on 154 inpatients exposed to patients with COVID-19 between October and December 2022. Fifty-two uninfected participants who were unvaccinated or immunosuppressed and had risk factors for severe COVID-19 were included. The primary endpoint was the COVID-19 incidence rate. Statistical analyses included the chi-square test, Fisher's exact test, and Mann-Whitney U test, as appropriate. Factors associated with COVID-19 incidence (p < 0.05) in univariate analysis were included in the multivariate logistic regression. Statistical significance was set at p < 0.05.
Results: Among the 52 participants, 14 and 38 were included in the CAS + IMD and non-CAS + IMD groups, respectively. The COVID-19 incidence rate was significantly lower in the CAS + IMD group than in the non-CAS + IMD group (14.3% vs. 52.6%, p = 0.013). Multivariate analysis identified CAS + IMD administration as significantly associated with reduced COVID-19 incidence (adjusted odds ratio [OR], 0.121; 95% confidence interval [CI], 0.020-0.710; p = 0.019), whereas long-term use of immunosuppressive therapy was associated with increased incidence (adjusted OR, 4.320; 95% CI, 1.090-17.126; p = 0.037).
Conclusions: CAS + IMD may be effective for post-exposure prophylaxis of COVID-19 during the Omicron BA.5 subvariant epidemic. However, prudent clinical use should consider the circulating variant profile. Further research is warranted to validate CAS + IMD's role in COVID-19 post-exposure prophylaxis.
Keywords: COVID-19; Casirivimab; Imdevimab; Omicron; Post-exposure prophylaxis.
. 2025 Oct 27;11(1):94.
doi: 10.1186/s40780-025-00501-x. Clinical efficacy of casirivimab and imdevimab in preventing COVID-19 in the Omicron BA.5 subvariant epidemic: a retrospective study
Mariko Ohtani[SUP] 1 2 [/SUP], Takuya Yokoo[SUP] 3 [/SUP], Taito Miyazaki[SUP] 4 5 [/SUP], Hiroshi Yasuda[SUP] 3 [/SUP], Eriko Nishikawa[SUP] 4 [/SUP], Manabu Tomida[SUP] 4 [/SUP], Mayumi Tsukada[SUP] 4 [/SUP], Emi Sato[SUP] 6 [/SUP], Shinobu Hirayama[SUP] 3 [/SUP], Hinako Murakami[SUP] 4 7 [/SUP], Sadako Yoshizawa[SUP] 7 8 [/SUP], Takahiro Matsumoto[SUP] 3 [/SUP], Kazuhiro Tateda[SUP] 4 7 8 [/SUP]
Affiliations
- PMID: 41146359
- PMCID: PMC12560490
- DOI: 10.1186/s40780-025-00501-x
Background: The neutralizing monoclonal antibody combination of casirivimab and imdevimab (CAS + IMD) is the only therapy approved for preventing coronavirus disease 2019 (COVID-19) following exposure to severe acute respiratory syndrome coronavirus 2. However, the efficacy of CAS + IMD against Omicron variants remains uncertain, with in vitro studies indicating reduced neutralizing activity. This study aimed to evaluate the clinical efficacy of CAS + IMD in preventing COVID-19 among uninfected hospitalized contacts of patients with COVID-19.
Methods: A retrospective chart review was conducted on 154 inpatients exposed to patients with COVID-19 between October and December 2022. Fifty-two uninfected participants who were unvaccinated or immunosuppressed and had risk factors for severe COVID-19 were included. The primary endpoint was the COVID-19 incidence rate. Statistical analyses included the chi-square test, Fisher's exact test, and Mann-Whitney U test, as appropriate. Factors associated with COVID-19 incidence (p < 0.05) in univariate analysis were included in the multivariate logistic regression. Statistical significance was set at p < 0.05.
Results: Among the 52 participants, 14 and 38 were included in the CAS + IMD and non-CAS + IMD groups, respectively. The COVID-19 incidence rate was significantly lower in the CAS + IMD group than in the non-CAS + IMD group (14.3% vs. 52.6%, p = 0.013). Multivariate analysis identified CAS + IMD administration as significantly associated with reduced COVID-19 incidence (adjusted odds ratio [OR], 0.121; 95% confidence interval [CI], 0.020-0.710; p = 0.019), whereas long-term use of immunosuppressive therapy was associated with increased incidence (adjusted OR, 4.320; 95% CI, 1.090-17.126; p = 0.037).
Conclusions: CAS + IMD may be effective for post-exposure prophylaxis of COVID-19 during the Omicron BA.5 subvariant epidemic. However, prudent clinical use should consider the circulating variant profile. Further research is warranted to validate CAS + IMD's role in COVID-19 post-exposure prophylaxis.
Keywords: COVID-19; Casirivimab; Imdevimab; Omicron; Post-exposure prophylaxis.