tetano
Editor, Senior Moderator
J Pharm Anal
. 2021 Nov 10.
doi: 10.1016/j.jpha.2021.11.003. Online ahead of print.
An outlook on coronavirus disease 2019 detection methods
Zahra Hassani Nejad[SUP] 1 [/SUP], Fataneh Fatemi[SUP] 2 [/SUP], Seyed Ehsan Ranaei Siadat[SUP] 3 [/SUP]
Affiliations
Abstract
Diagnostic testing plays a fundamental role in the mitigation and containment of coronavirus disease 2019 (COVID-19), as it enables immediate quarantine of those who are infected and contagious and is essential for the epidemiological characterization of the virus and estimating the number of infected cases worldwide. Confirmation of viral infections, such as COVID-19, can be achieved through two general approaches: nucleic acid amplification tests (NAATs) or molecular tests and serological or antibody-based tests. The genetic material of the pathogen is detected in NAAT, and in serological tests, host antibodies produced in response to the pathogen are identified. Other methods of diagnosing COVID-19 include radiological imaging of the lungs and in vitro detection of viral antigens. This review covers the different approaches available for diagnosing COVID-19 by outlining their advantages and shortcomings, as well as appropriate indications for more accurate testing.
Keywords: COVID-19; Diagnostics; Nucleic acid amplification tests; Serological tests.
. 2021 Nov 10.
doi: 10.1016/j.jpha.2021.11.003. Online ahead of print.
An outlook on coronavirus disease 2019 detection methods
Zahra Hassani Nejad[SUP] 1 [/SUP], Fataneh Fatemi[SUP] 2 [/SUP], Seyed Ehsan Ranaei Siadat[SUP] 3 [/SUP]
Affiliations
- PMID: 34777894
- PMCID: PMC8578030
- DOI: 10.1016/j.jpha.2021.11.003
Abstract
Diagnostic testing plays a fundamental role in the mitigation and containment of coronavirus disease 2019 (COVID-19), as it enables immediate quarantine of those who are infected and contagious and is essential for the epidemiological characterization of the virus and estimating the number of infected cases worldwide. Confirmation of viral infections, such as COVID-19, can be achieved through two general approaches: nucleic acid amplification tests (NAATs) or molecular tests and serological or antibody-based tests. The genetic material of the pathogen is detected in NAAT, and in serological tests, host antibodies produced in response to the pathogen are identified. Other methods of diagnosing COVID-19 include radiological imaging of the lungs and in vitro detection of viral antigens. This review covers the different approaches available for diagnosing COVID-19 by outlining their advantages and shortcomings, as well as appropriate indications for more accurate testing.
Keywords: COVID-19; Diagnostics; Nucleic acid amplification tests; Serological tests.