tetano
Editor, Senior Moderator
J Perinat Med
. 2022 Jan 21.
doi: 10.1515/jpm-2021-0657. Online ahead of print.
Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study
Giuseppe Rizzo[SUP] 1 2 [/SUP], Ilenia Mappa[SUP] 1 [/SUP], Maria Elena Pietrolucci[SUP] 1 [/SUP], Jia Li Angela Lu[SUP] 1 [/SUP], Alexander Makatsarya[SUP] 2 [/SUP], Francesco D'Antonio[SUP] 3 [/SUP]
Affiliations
Abstract
Objectives: To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect umbilical vein blood flow (UVBF) and fetal cardiac function.
Methods: Prospective case-control study of consecutive pregnancies complicated by SARS-CoV-2 infection during the second half of pregnancy matched with unaffected women. Measurements of UVBF normalized for fetal abdominal circumference (UVBF/AC), atrial area (AA) and ventricular sphericity indices (SI) were compared between the two study groups. Chi-square and Mann-Whitney U tests were sued to analyze the data.
Results: Fifty-four consecutive pregnancies complicated and 108 not complicated by SARS-CoV-2 infection were included. The median gestational age at infection was 30.2 (interquartile range [IQR] 26.2 34.1). General baseline and pregnancy characteristics were similar between pregnant women with compared to those without SARS-CoV-2 infection. There was no difference in UVBF/AC (study groups z value -0.11 vs. 0.14 control p 0.751) values between pregnancies complicated compared to those not complicated by SARS-CoV-2 infection. Likewise, there was no difference in the left and right AA (left 1.30 vs. 1.28 p=0.221 and right 1.33 vs. 1.31 p=0.324) and SI (left 1.75 vs. 1.77 p=0.208 and right 1.51 vs. 1.54 p=0.121) between the two groups.
Conclusions: SARS-CoV-2 infection does not affect UVBF and fetal cardiac function in uncomplicated pregnancies.
Keywords: COVID-19; fetal cardiac function; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; umbilical vein flow.
. 2022 Jan 21.
doi: 10.1515/jpm-2021-0657. Online ahead of print.
Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study
Giuseppe Rizzo[SUP] 1 2 [/SUP], Ilenia Mappa[SUP] 1 [/SUP], Maria Elena Pietrolucci[SUP] 1 [/SUP], Jia Li Angela Lu[SUP] 1 [/SUP], Alexander Makatsarya[SUP] 2 [/SUP], Francesco D'Antonio[SUP] 3 [/SUP]
Affiliations
- PMID: 35073616
- DOI: 10.1515/jpm-2021-0657
Abstract
Objectives: To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect umbilical vein blood flow (UVBF) and fetal cardiac function.
Methods: Prospective case-control study of consecutive pregnancies complicated by SARS-CoV-2 infection during the second half of pregnancy matched with unaffected women. Measurements of UVBF normalized for fetal abdominal circumference (UVBF/AC), atrial area (AA) and ventricular sphericity indices (SI) were compared between the two study groups. Chi-square and Mann-Whitney U tests were sued to analyze the data.
Results: Fifty-four consecutive pregnancies complicated and 108 not complicated by SARS-CoV-2 infection were included. The median gestational age at infection was 30.2 (interquartile range [IQR] 26.2 34.1). General baseline and pregnancy characteristics were similar between pregnant women with compared to those without SARS-CoV-2 infection. There was no difference in UVBF/AC (study groups z value -0.11 vs. 0.14 control p 0.751) values between pregnancies complicated compared to those not complicated by SARS-CoV-2 infection. Likewise, there was no difference in the left and right AA (left 1.30 vs. 1.28 p=0.221 and right 1.33 vs. 1.31 p=0.324) and SI (left 1.75 vs. 1.77 p=0.208 and right 1.51 vs. 1.54 p=0.121) between the two groups.
Conclusions: SARS-CoV-2 infection does not affect UVBF and fetal cardiac function in uncomplicated pregnancies.
Keywords: COVID-19; fetal cardiac function; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; umbilical vein flow.