tetano
Editor, Senior Moderator
J Perinat Med
. 2023 Feb 17.
doi: 10.1515/jpm-2022-0463. Online ahead of print.
Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes
Christos-Georgios Kontovazainitis[SUP] 1 [/SUP], Georgios N Katsaras[SUP] 1 [/SUP], Dimitra Gialamprinou[SUP] 1 [/SUP], Georgios Mitsiakos[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: Although the vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS Cov-2) is considered safe during pregnancy, vaccine hesitancy among pregnant women is high. The results of published observational studies addressing the issue of Covid-19 vaccination's efficacy and safety during pregnancy need to be summarized.
Content: This systematic review compares the incidence of major maternal and neonatal outcomes between SARS Cov-2 vaccinated and unvaccinated pregnant women. The included studies enrolled pregnant women of any age and any trimester. Medline-Pubmed, Scopus, Cochrane Library, and grey literature were searched until the 28th of May 2022, and 2,947 studies were found.
Summary: Seven observational cohort studies, enrolling 67,274 pregnant women, were selected. When comparing vaccinated and unvaccinated pregnant women, SARS Cov-2 vaccines were not associated with major maternal and neonatal adverse events. The rate of SARS Cov-2 infections among vaccinated pregnant women compared to unvaccinated is significantly reduced by 43%.
Outlook: SARS Cov-2 vaccination in pregnant women is effective and safe. The results are promising, but caution is advised due to some limitations: only observational studies addressing this issue were found. Parallelly, the enrolled populations and the intervention (vaccination type and the number of doses) were not homogeneous.
Keywords: COVID-19; infant; newborn; obstetrics; pregnancy; vaccination.
. 2023 Feb 17.
doi: 10.1515/jpm-2022-0463. Online ahead of print.
Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes
Christos-Georgios Kontovazainitis[SUP] 1 [/SUP], Georgios N Katsaras[SUP] 1 [/SUP], Dimitra Gialamprinou[SUP] 1 [/SUP], Georgios Mitsiakos[SUP] 1 [/SUP]
Affiliations
- PMID: 36800343
- DOI: 10.1515/jpm-2022-0463
Abstract
Objectives: Although the vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS Cov-2) is considered safe during pregnancy, vaccine hesitancy among pregnant women is high. The results of published observational studies addressing the issue of Covid-19 vaccination's efficacy and safety during pregnancy need to be summarized.
Content: This systematic review compares the incidence of major maternal and neonatal outcomes between SARS Cov-2 vaccinated and unvaccinated pregnant women. The included studies enrolled pregnant women of any age and any trimester. Medline-Pubmed, Scopus, Cochrane Library, and grey literature were searched until the 28th of May 2022, and 2,947 studies were found.
Summary: Seven observational cohort studies, enrolling 67,274 pregnant women, were selected. When comparing vaccinated and unvaccinated pregnant women, SARS Cov-2 vaccines were not associated with major maternal and neonatal adverse events. The rate of SARS Cov-2 infections among vaccinated pregnant women compared to unvaccinated is significantly reduced by 43%.
Outlook: SARS Cov-2 vaccination in pregnant women is effective and safe. The results are promising, but caution is advised due to some limitations: only observational studies addressing this issue were found. Parallelly, the enrolled populations and the intervention (vaccination type and the number of doses) were not homogeneous.
Keywords: COVID-19; infant; newborn; obstetrics; pregnancy; vaccination.