tetano
Editor, Senior Moderator
J Perinat Med
. 2020 Dec 1;49(2):141-147.
doi: 10.1515/jpm-2020-0403. Print 2021 Feb 23.
Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort
Esin Merve Erol Ko?[SUP] 1 [/SUP], Rahime Bedir Fındık[SUP] 1 [/SUP], Hatice Akkaya[SUP] 1 [/SUP], Işılay Karadağ[SUP] 1 [/SUP], Eda ?zden Tokalıoğlu[SUP] 1 [/SUP], ?zlem Moraloğlu Tekin[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: To evaluate the relationship between Coronavirus Disease 2019 (COVID-19) in pregnancy and adverse perinatal outcomes. The secondary aim is to analyze the diagnostic value of hematologic parameters in COVID-19 complicated pregnancies.
Methods: The current study is conducted in a high volume tertiary obstetrics center burdened by COVID-19 pandemics, in Turkey. In this cohort study, perinatal outcomes and complete blood count indices performed at the time of admission of 39 pregnancies (Study group) complicated by COVID-19 were compared with 69 uncomplicated pregnancies (Control group).
Results: There was no significant difference between the obstetric and neonatal outcomes of pregnancies with COVID-19 compared to data of healthy pregnancies, except the increased C-section rate (p=0.026). Monocyte count, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) were significantly increased (p<0.0001, p=0.009, p=0.043, p<0.0001, respectively) whereas the MPV and plateletcrit were significantly decreased (p=0.001, p=0.008) in pregnants with COVID-19. ROC analysis revealed that the optimal cut-off value for MLR was 0.354 which indicated 96.7% specificity and 59.5% sensitivity in diagnosis of pregnant women with COVID-19. A strong positive correlation was found between the MLR and the presence of cough symptom (r=41.4, p=<0.0001).
Conclusions: The study revealed that, pregnancies complicated by COVID-19 is not related with adverse perinatal outcomes. MLR may serve as a supportive diagnostic parameter together with the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in assessment of COVID-19 in pregnant cohort.
Keywords: COVID-19; blood cell count; pregnancy; pregnancy outcome.
. 2020 Dec 1;49(2):141-147.
doi: 10.1515/jpm-2020-0403. Print 2021 Feb 23.
Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort
Esin Merve Erol Ko?[SUP] 1 [/SUP], Rahime Bedir Fındık[SUP] 1 [/SUP], Hatice Akkaya[SUP] 1 [/SUP], Işılay Karadağ[SUP] 1 [/SUP], Eda ?zden Tokalıoğlu[SUP] 1 [/SUP], ?zlem Moraloğlu Tekin[SUP] 1 [/SUP]
Affiliations
- PMID: 33544531
- DOI: 10.1515/jpm-2020-0403
Abstract
Objectives: To evaluate the relationship between Coronavirus Disease 2019 (COVID-19) in pregnancy and adverse perinatal outcomes. The secondary aim is to analyze the diagnostic value of hematologic parameters in COVID-19 complicated pregnancies.
Methods: The current study is conducted in a high volume tertiary obstetrics center burdened by COVID-19 pandemics, in Turkey. In this cohort study, perinatal outcomes and complete blood count indices performed at the time of admission of 39 pregnancies (Study group) complicated by COVID-19 were compared with 69 uncomplicated pregnancies (Control group).
Results: There was no significant difference between the obstetric and neonatal outcomes of pregnancies with COVID-19 compared to data of healthy pregnancies, except the increased C-section rate (p=0.026). Monocyte count, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) were significantly increased (p<0.0001, p=0.009, p=0.043, p<0.0001, respectively) whereas the MPV and plateletcrit were significantly decreased (p=0.001, p=0.008) in pregnants with COVID-19. ROC analysis revealed that the optimal cut-off value for MLR was 0.354 which indicated 96.7% specificity and 59.5% sensitivity in diagnosis of pregnant women with COVID-19. A strong positive correlation was found between the MLR and the presence of cough symptom (r=41.4, p=<0.0001).
Conclusions: The study revealed that, pregnancies complicated by COVID-19 is not related with adverse perinatal outcomes. MLR may serve as a supportive diagnostic parameter together with the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in assessment of COVID-19 in pregnant cohort.
Keywords: COVID-19; blood cell count; pregnancy; pregnancy outcome.