tetano
Editor, Senior Moderator
J Pediatr
. 2023 May 16;113491.
doi: 10.1016/j.jpeds.2023.113491. Online ahead of print. RSV, Influenza, and COVID-19 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season
Suchitra Rao[SUP] 1 [/SUP], Isaac Armistead[SUP] 2 [/SUP], Amy Tyler[SUP] 3 [/SUP], Madelyn Lensing[SUP] 2 [/SUP], Samuel R Dominguez[SUP] 3 [/SUP], Nisha B Alden[SUP] 2 [/SUP]
Affiliations
Objective: To compare demographic characteristics, clinical features, and outcomes of children hospitalized with RSV, influenza, or SARS-CoV-2 during their co-circulation 2021-2022 respiratory virus season METHODS: We conducted a retrospective cohort study using Colorado's hospital respiratory surveillance data comparing COVID-19-, influenza-, and RSV-hospitalized cases < 18 years of age admitted and undergoing standardized molecular testing between October 1, 2021, and April 30, 2022. Multivariable log-binomial regression modeling evaluated associations between pathogen type and diagnosis, ICU admission, hospital length of stay, and highest level of respiratory support received.
Results: Among 847 hospitalized cases, 490 (57.9%) were RSV-associated, 306 (36.1%) were COVID-19-associated, and 51 (6%) were influenza-associated. Most RSV cases were <4 years of age (92.9%), whereas influenza hospitalizations were observed in older children. RSV cases were more likely to require oxygen support higher than nasal cannula compared with COVID-19 and influenza cases (p<.0001), though COVID-19 cases were more likely to require invasive mechanical ventilation than influenza and RSV cases (<.0001). Using multivariable log-binomial regression analyses, compared with children with COVID-19, the risk of ICU admission was highest among children with influenza (RR 1.97, 95% CI 1.22-3.19), whereas the risk of pneumonia, bronchiolitis, longer hospital length of stay, and need for oxygen were more likely among children with RSV.
Conclusions: In a season with respiratory pathogen co-circulation, children were hospitalized most commonly due to RSV, were younger, and required higher oxygen support and non-invasive ventilation compared with children with influenza and COVID-19.
Keywords: COVID-19; RSV; bronchiolitis; croup; influenza; respiratory infection.
. 2023 May 16;113491.
doi: 10.1016/j.jpeds.2023.113491. Online ahead of print. RSV, Influenza, and COVID-19 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season
Suchitra Rao[SUP] 1 [/SUP], Isaac Armistead[SUP] 2 [/SUP], Amy Tyler[SUP] 3 [/SUP], Madelyn Lensing[SUP] 2 [/SUP], Samuel R Dominguez[SUP] 3 [/SUP], Nisha B Alden[SUP] 2 [/SUP]
Affiliations
- PMID: 37201680
- DOI: 10.1016/j.jpeds.2023.113491
Objective: To compare demographic characteristics, clinical features, and outcomes of children hospitalized with RSV, influenza, or SARS-CoV-2 during their co-circulation 2021-2022 respiratory virus season METHODS: We conducted a retrospective cohort study using Colorado's hospital respiratory surveillance data comparing COVID-19-, influenza-, and RSV-hospitalized cases < 18 years of age admitted and undergoing standardized molecular testing between October 1, 2021, and April 30, 2022. Multivariable log-binomial regression modeling evaluated associations between pathogen type and diagnosis, ICU admission, hospital length of stay, and highest level of respiratory support received.
Results: Among 847 hospitalized cases, 490 (57.9%) were RSV-associated, 306 (36.1%) were COVID-19-associated, and 51 (6%) were influenza-associated. Most RSV cases were <4 years of age (92.9%), whereas influenza hospitalizations were observed in older children. RSV cases were more likely to require oxygen support higher than nasal cannula compared with COVID-19 and influenza cases (p<.0001), though COVID-19 cases were more likely to require invasive mechanical ventilation than influenza and RSV cases (<.0001). Using multivariable log-binomial regression analyses, compared with children with COVID-19, the risk of ICU admission was highest among children with influenza (RR 1.97, 95% CI 1.22-3.19), whereas the risk of pneumonia, bronchiolitis, longer hospital length of stay, and need for oxygen were more likely among children with RSV.
Conclusions: In a season with respiratory pathogen co-circulation, children were hospitalized most commonly due to RSV, were younger, and required higher oxygen support and non-invasive ventilation compared with children with influenza and COVID-19.
Keywords: COVID-19; RSV; bronchiolitis; croup; influenza; respiratory infection.