tetano
Editor, Senior Moderator
J Pediatr Hematol Oncol
. 2022 Apr 1;44(3):e812-e815.
doi: 10.1097/MPH.0000000000002370.
Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient With Systemic Lupus Erythematosus in the Setting of MIS-C
Eman T Al-Antary[SUP] 1 [/SUP], Rewa Arar[SUP] 1 [/SUP], Yogindra Persaud[SUP] 1 [/SUP], Basil M Fathalla[SUP] 2 [/SUP], Madhvi Rajpurkar[SUP] 1 [/SUP], Kanta Bhambhani[SUP] 1 [/SUP]
Affiliations
Abstract
The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE.
. 2022 Apr 1;44(3):e812-e815.
doi: 10.1097/MPH.0000000000002370.
Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient With Systemic Lupus Erythematosus in the Setting of MIS-C
Eman T Al-Antary[SUP] 1 [/SUP], Rewa Arar[SUP] 1 [/SUP], Yogindra Persaud[SUP] 1 [/SUP], Basil M Fathalla[SUP] 2 [/SUP], Madhvi Rajpurkar[SUP] 1 [/SUP], Kanta Bhambhani[SUP] 1 [/SUP]
Affiliations
- PMID: 35319513
- DOI: 10.1097/MPH.0000000000002370
Abstract
The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE.