tetano
Editor, Senior Moderator
J Pediatr Hematol Oncol
. 2020 Dec 23;Publish Ahead of Print.
doi: 10.1097/MPH.0000000000002037. Online ahead of print.
Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis
Yogindra Persaud[SUP] 1 [/SUP], Mark Shamoun, Meera Chitlur, Kyle J Des Rosier, Jeffrey W Taub
Affiliations
Abstract
The Coronavirus Disease 2019 (COVID-19) pandemic has become the worst pandemic in modern history. The lack of prior immunity to the virus has resulted in a high mortality rate, though children have fared better than adults, overall. We present a case of a child who developed B-cell acute lymphoblastic leukemia 1 week following a symptomatic COVID-19 infection. It is possible that this viral infection provided the "second hit" posited to occur in pediatric leukemogenesis as proposed by Dr Greaves, with his initial viral exposure occurring several weeks earlier.
. 2020 Dec 23;Publish Ahead of Print.
doi: 10.1097/MPH.0000000000002037. Online ahead of print.
Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis
Yogindra Persaud[SUP] 1 [/SUP], Mark Shamoun, Meera Chitlur, Kyle J Des Rosier, Jeffrey W Taub
Affiliations
- PMID: 33369996
- DOI: 10.1097/MPH.0000000000002037
Abstract
The Coronavirus Disease 2019 (COVID-19) pandemic has become the worst pandemic in modern history. The lack of prior immunity to the virus has resulted in a high mortality rate, though children have fared better than adults, overall. We present a case of a child who developed B-cell acute lymphoblastic leukemia 1 week following a symptomatic COVID-19 infection. It is possible that this viral infection provided the "second hit" posited to occur in pediatric leukemogenesis as proposed by Dr Greaves, with his initial viral exposure occurring several weeks earlier.