tetano
Editor, Senior Moderator
J Pediatr Gastroenterol Nutr
. 2020 Dec 9.
doi: 10.1097/MPG.0000000000003005. Online ahead of print.
The Effect of Helicobacter Pylori on the Presentation and Clinical Course of COVID-19 Infection
Necati Balamtekin[SUP] 1 [/SUP], Cumhur Artuk[SUP] 2 [/SUP], Melike Arslan[SUP] 1 [/SUP], Mustafa G?lşen[SUP] 3 [/SUP]
Affiliations
Abstract
Objectives/Introduction: Novel coronavirus 2019 (COVID-19) binds angiotensin-converting enzyme-2 (ACE-2) receptors to enter the cell. These receptors are widely expressed in the intestine, and COVID-19 may cause gastrointestinal symptoms via these receptors during the course of the disease. Helicobacter pylori is known to increase the expression of ACE-2 receptors in the gastrointestinal tract. The aim of this study was to investigate the effects of H pylori on the presentation and clinical course of COVID-19 infections.
Methods: This study was carried out from June 1 to July 20, 2020. Patients diagnosed with COVID-19 infections by PCR tests were included in the study. Antigen screening tests were performed on stool samples to determine the presence of H pylori. All patients were evaluated for manifestations of COVID-19 infection, severity of the course, hospitalized days due to the virus and outcome of the disease process.
Results: Of 108 COVID-19 positive patients evaluated, 31 with a mean age of 49.54 ? 17.94 years were H pylori-positive [(8 females (25.8%)] and 77 with a mean age of 47.85 ? 20.51 years; [31 females (%40.3)] were H pylori-negative. Abdominal pain (19.4% vs 2.6%) and diarrhea (32.3% vs 9.1%) were significantly higher in patients with H pylori than those without (p = 0.007 and p = 0.006, respectively). There was no statistically significant difference between H pylori positivity and the number of hospitalized days, the severity of the course of COVID-19 infection, or the outcome of the disease (p > 0.05).
Conclusion: Our results revealed that the findings of abdominal pain and diarrhea strongly correlated with the presence of H pylori in COVID-19 patients.
. 2020 Dec 9.
doi: 10.1097/MPG.0000000000003005. Online ahead of print.
The Effect of Helicobacter Pylori on the Presentation and Clinical Course of COVID-19 Infection
Necati Balamtekin[SUP] 1 [/SUP], Cumhur Artuk[SUP] 2 [/SUP], Melike Arslan[SUP] 1 [/SUP], Mustafa G?lşen[SUP] 3 [/SUP]
Affiliations
- PMID: 33306581
- DOI: 10.1097/MPG.0000000000003005
Abstract
Objectives/Introduction: Novel coronavirus 2019 (COVID-19) binds angiotensin-converting enzyme-2 (ACE-2) receptors to enter the cell. These receptors are widely expressed in the intestine, and COVID-19 may cause gastrointestinal symptoms via these receptors during the course of the disease. Helicobacter pylori is known to increase the expression of ACE-2 receptors in the gastrointestinal tract. The aim of this study was to investigate the effects of H pylori on the presentation and clinical course of COVID-19 infections.
Methods: This study was carried out from June 1 to July 20, 2020. Patients diagnosed with COVID-19 infections by PCR tests were included in the study. Antigen screening tests were performed on stool samples to determine the presence of H pylori. All patients were evaluated for manifestations of COVID-19 infection, severity of the course, hospitalized days due to the virus and outcome of the disease process.
Results: Of 108 COVID-19 positive patients evaluated, 31 with a mean age of 49.54 ? 17.94 years were H pylori-positive [(8 females (25.8%)] and 77 with a mean age of 47.85 ? 20.51 years; [31 females (%40.3)] were H pylori-negative. Abdominal pain (19.4% vs 2.6%) and diarrhea (32.3% vs 9.1%) were significantly higher in patients with H pylori than those without (p = 0.007 and p = 0.006, respectively). There was no statistically significant difference between H pylori positivity and the number of hospitalized days, the severity of the course of COVID-19 infection, or the outcome of the disease (p > 0.05).
Conclusion: Our results revealed that the findings of abdominal pain and diarrhea strongly correlated with the presence of H pylori in COVID-19 patients.