tetano
Editor, Senior Moderator
J Pediatr
. 2022 Oct 14;S0022-3476(22)00896-4.
doi: 10.1016/j.jpeds.2022.09.059. Online ahead of print.
Effectiveness of BNT162b2 Vaccination During Pregnancy in Preventing Hospitalization for SARS-CoV-2 in Infants
Dana Danino[SUP] 1 [/SUP], Liat Ashkenazi-Hoffnung[SUP] 2 [/SUP], Alejandro Diaz[SUP] 3 [/SUP], Amir Dov Erps[SUP] 4 [/SUP], Noa Eliakim-Raz[SUP] 5 [/SUP], Yonat Shemer Avni[SUP] 6 [/SUP], David Greenberg[SUP] 7 [/SUP], Noga Givon-Lavi[SUP] 7 [/SUP], Ilan Youngster[SUP] 8 [/SUP]
Affiliations
Abstract
Objective: To Assessthe clinical effectiveness of the BNT162b2 vaccine during pregnancy in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalizations of infants.
Study design: A retrospective, multicenter, 1:3 case-control (test-negative) study. Symptomatic hospitalized infants <6 months, with positive SARS-CoV-2 polymerase chain reaction (PCR) test between 1/3/2021-31/11/2021 were matched by age and time to negative controls, hospitalized with symptoms compatible with SARS-CoV-2 infection. Mothers were defined as fully vaccinated; received 2 doses of BNT162b2 with the second given 2 weeks to 6 months before delivery, or partially vaccinated; received only one dose or 2 doses with the second given >6 months or <2 weeks before delivery. Severe SARS-CoV-2 was defined as need for assisted ventilation.
Results: 116 SARS-CoV-2 positive infants were matched to 348 negative controls with symptoms compatible with SARS-CoV-2 infection. The effectiveness of fully vaccinated mothers was 61.6% (CI: 31.9-78.4) and the effectiveness of partially vaccinated mothers was not significant. Effectiveness was higher in infants 0-2 vs. 3-6 months of age. The effectiveness (57.1%, CI: 22.8-76.4) was similar when excluding mothers who were infected with SARS-CoV-2 during pregnancy. OR of severe infection in infants born to unvaccinated versus fully vaccinated mothers was 5.8.
Conclusions: At least 2 doses of BNT162b2 vaccine administered during the second or third trimester of pregnancy had an effectiveness of 61.6% in reduction of hospitalization for SARS-CoV-2 infection in infants <6 months.
Keywords: Maternal vaccination; SARS-CoV-2; infants’ hospitalizations; pregnancy.
. 2022 Oct 14;S0022-3476(22)00896-4.
doi: 10.1016/j.jpeds.2022.09.059. Online ahead of print.
Effectiveness of BNT162b2 Vaccination During Pregnancy in Preventing Hospitalization for SARS-CoV-2 in Infants
Dana Danino[SUP] 1 [/SUP], Liat Ashkenazi-Hoffnung[SUP] 2 [/SUP], Alejandro Diaz[SUP] 3 [/SUP], Amir Dov Erps[SUP] 4 [/SUP], Noa Eliakim-Raz[SUP] 5 [/SUP], Yonat Shemer Avni[SUP] 6 [/SUP], David Greenberg[SUP] 7 [/SUP], Noga Givon-Lavi[SUP] 7 [/SUP], Ilan Youngster[SUP] 8 [/SUP]
Affiliations
- PMID: 36252864
- DOI: 10.1016/j.jpeds.2022.09.059
Abstract
Objective: To Assessthe clinical effectiveness of the BNT162b2 vaccine during pregnancy in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalizations of infants.
Study design: A retrospective, multicenter, 1:3 case-control (test-negative) study. Symptomatic hospitalized infants <6 months, with positive SARS-CoV-2 polymerase chain reaction (PCR) test between 1/3/2021-31/11/2021 were matched by age and time to negative controls, hospitalized with symptoms compatible with SARS-CoV-2 infection. Mothers were defined as fully vaccinated; received 2 doses of BNT162b2 with the second given 2 weeks to 6 months before delivery, or partially vaccinated; received only one dose or 2 doses with the second given >6 months or <2 weeks before delivery. Severe SARS-CoV-2 was defined as need for assisted ventilation.
Results: 116 SARS-CoV-2 positive infants were matched to 348 negative controls with symptoms compatible with SARS-CoV-2 infection. The effectiveness of fully vaccinated mothers was 61.6% (CI: 31.9-78.4) and the effectiveness of partially vaccinated mothers was not significant. Effectiveness was higher in infants 0-2 vs. 3-6 months of age. The effectiveness (57.1%, CI: 22.8-76.4) was similar when excluding mothers who were infected with SARS-CoV-2 during pregnancy. OR of severe infection in infants born to unvaccinated versus fully vaccinated mothers was 5.8.
Conclusions: At least 2 doses of BNT162b2 vaccine administered during the second or third trimester of pregnancy had an effectiveness of 61.6% in reduction of hospitalization for SARS-CoV-2 infection in infants <6 months.
Keywords: Maternal vaccination; SARS-CoV-2; infants’ hospitalizations; pregnancy.