tetano
Editor, Senior Moderator
J Pediatr
. 2020 Jul 15;S0022-3476(20)30888-X.
doi: 10.1016/j.jpeds.2020.07.039. Online ahead of print.
Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with COVID-19 in New York City
Kim R Derespina[SUP] 1 [/SUP], Shubhi Kaushik[SUP] 2 [/SUP], Anna Plichta[SUP] 1 [/SUP], Edward E Conway Jr[SUP] 3 [/SUP], Asher Bercow[SUP] 3 [/SUP], Jaeun Choi[SUP] 4 [/SUP], Ruth Eisenberg[SUP] 4 [/SUP], Jennifer Gillen[SUP] 2 [/SUP], Anita I Sen[SUP] 5 [/SUP], Claire M Hennigan[SUP] 6 [/SUP], Lillian M Zerihun[SUP] 7 [/SUP], Sule Doymaz[SUP] 8 [/SUP], Michael A Keenaghan[SUP] 9 [/SUP], Stephanie Jarrin[SUP] 10 [/SUP], Franscene Oulds[SUP] 11 [/SUP], Manoj Gupta[SUP] 12 [/SUP], Louisdon Pierre[SUP] 13 [/SUP], Melissa Grageda[SUP] 14 [/SUP], H Michael Ushay[SUP] 1 [/SUP], Vinay M Nadkarni[SUP] 15 [/SUP], Michael S D Agus[SUP] 16 [/SUP], Shivanand S Medar[SUP] 17 [/SUP]
Affiliations
Abstract
Objectives: To describe the clinical manifestations and outcomes of critically ill children with coronavirus disease-19 (COVID-19) in New York City.
Study design: Retrospective observational study of children 1 month to 21 years admitted March 14 to May 2, 2020 to 9 New York City pediatric intensive care units (PICUs) with SARS-CoV-2 infection.
Results: Of 70 children admitted to PICUs: median age 15 [IQR 9, 19] years; 61.4% male; 38.6% Hispanic; 32.9% Black; 74.3% with comorbidities. Fever (72.9%) and cough (71.4%) were the common presenting symptoms. Twelve patients (17%) met severe sepsis criteria; 14 (20%) required vasopressor support; 21 (30%) developed acute respiratory distress syndrome (ARDS); 9 (12.9%) met acute kidney injury criteria; 1 (1.4%) required renal replacement therapy, and 2 (2.8%) had cardiac arrest. For treatment, 27 (38.6%) patients received hydroxychloroquine; 13 (18.6%) remdesivir; 23 (32.9%) corticosteroids; 3 (4.3%) tocilizumab; 1 (1.4%) anakinra; no patient was given immunoglobulin or convalescent plasma. Forty-nine (70%) patients required respiratory support: 14 (20.0%) non-invasive mechanical ventilation, 20 (28.6%) invasive mechanical ventilation (IMV), 7 (10%) prone position, 2 (2.8%) inhaled nitric oxide, and 1 (1.4%) extracorporeal membrane oxygenation. Nine (45%) of the 20 patients requiring IMV were extubated by day 14 with median IMV duration of 218 [IQR 79, 310.4] hours. Presence of ARDS was significantly associated with duration of PICU and hospital stay, and lower probability of PICU and hospital discharge at hospital day 14 (P < .05 for all).
Conclusions: Critically ill children with COVID-19 predominantly are adolescents, have comorbidities, and require some form of respiratory support. The presence of ARDS is significantly associated with prolonged PICU and hospital stay.
Keywords: Pediatric ARDS; pediatric respiratory failure; pediatric viral sepsis.
. 2020 Jul 15;S0022-3476(20)30888-X.
doi: 10.1016/j.jpeds.2020.07.039. Online ahead of print.
Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with COVID-19 in New York City
Kim R Derespina[SUP] 1 [/SUP], Shubhi Kaushik[SUP] 2 [/SUP], Anna Plichta[SUP] 1 [/SUP], Edward E Conway Jr[SUP] 3 [/SUP], Asher Bercow[SUP] 3 [/SUP], Jaeun Choi[SUP] 4 [/SUP], Ruth Eisenberg[SUP] 4 [/SUP], Jennifer Gillen[SUP] 2 [/SUP], Anita I Sen[SUP] 5 [/SUP], Claire M Hennigan[SUP] 6 [/SUP], Lillian M Zerihun[SUP] 7 [/SUP], Sule Doymaz[SUP] 8 [/SUP], Michael A Keenaghan[SUP] 9 [/SUP], Stephanie Jarrin[SUP] 10 [/SUP], Franscene Oulds[SUP] 11 [/SUP], Manoj Gupta[SUP] 12 [/SUP], Louisdon Pierre[SUP] 13 [/SUP], Melissa Grageda[SUP] 14 [/SUP], H Michael Ushay[SUP] 1 [/SUP], Vinay M Nadkarni[SUP] 15 [/SUP], Michael S D Agus[SUP] 16 [/SUP], Shivanand S Medar[SUP] 17 [/SUP]
Affiliations
- PMID: 32681989
- DOI: 10.1016/j.jpeds.2020.07.039
Abstract
Objectives: To describe the clinical manifestations and outcomes of critically ill children with coronavirus disease-19 (COVID-19) in New York City.
Study design: Retrospective observational study of children 1 month to 21 years admitted March 14 to May 2, 2020 to 9 New York City pediatric intensive care units (PICUs) with SARS-CoV-2 infection.
Results: Of 70 children admitted to PICUs: median age 15 [IQR 9, 19] years; 61.4% male; 38.6% Hispanic; 32.9% Black; 74.3% with comorbidities. Fever (72.9%) and cough (71.4%) were the common presenting symptoms. Twelve patients (17%) met severe sepsis criteria; 14 (20%) required vasopressor support; 21 (30%) developed acute respiratory distress syndrome (ARDS); 9 (12.9%) met acute kidney injury criteria; 1 (1.4%) required renal replacement therapy, and 2 (2.8%) had cardiac arrest. For treatment, 27 (38.6%) patients received hydroxychloroquine; 13 (18.6%) remdesivir; 23 (32.9%) corticosteroids; 3 (4.3%) tocilizumab; 1 (1.4%) anakinra; no patient was given immunoglobulin or convalescent plasma. Forty-nine (70%) patients required respiratory support: 14 (20.0%) non-invasive mechanical ventilation, 20 (28.6%) invasive mechanical ventilation (IMV), 7 (10%) prone position, 2 (2.8%) inhaled nitric oxide, and 1 (1.4%) extracorporeal membrane oxygenation. Nine (45%) of the 20 patients requiring IMV were extubated by day 14 with median IMV duration of 218 [IQR 79, 310.4] hours. Presence of ARDS was significantly associated with duration of PICU and hospital stay, and lower probability of PICU and hospital discharge at hospital day 14 (P < .05 for all).
Conclusions: Critically ill children with COVID-19 predominantly are adolescents, have comorbidities, and require some form of respiratory support. The presence of ARDS is significantly associated with prolonged PICU and hospital stay.
Keywords: Pediatric ARDS; pediatric respiratory failure; pediatric viral sepsis.