tetano
Editor, Senior Moderator
J Paediatr Child Health
. 2021 Aug 3.
doi: 10.1111/jpc.15674. Online ahead of print.
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus-2 pandemic in Turkey: A single-centre experience
Zeynep Savas Sen[SUP] 1 [/SUP], Gonul Tanir[SUP] 1 [/SUP], Ruveyda Gumuser Cinni[SUP] 1 [/SUP], Mutlu Uysal Yazici[SUP] 2 [/SUP], Tamer Yoldas[SUP] 3 [/SUP], Zeynelabidin Ozturk[SUP] 2 [/SUP], Mete Han Kizilkaya[SUP] 3 [/SUP], Suna Ozdem[SUP] 1 [/SUP], Rumeysa Yalcinkaya[SUP] 1 [/SUP], Caner Ozturk[SUP] 4 [/SUP], Aslihan Yuce Sezen[SUP] 4 [/SUP], Semanur Ozdel[SUP] 5 [/SUP], Betul Emine Derinkuyu[SUP] 6 [/SUP], Meltem Polat[SUP] 1 [/SUP], Fatma Nur Oz[SUP] 1 [/SUP]
Affiliations
Abstract
Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may result in a life-threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS-C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS-C.
Methods: We performed a retrospective study of patients with MIS-C managed between August 2020 and March 2021 at Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital in Turkey.
Results: A total of 45 patients (23 male, 51%) with a median age of 8.7 years (interquartile range: 5.6-11.7 years) were enrolled to study. The SARS-CoV-2 serology was positive in 43 (95%) patients. Organ-system involvement included the dermatologic in 41 (91%), cardiovascular in 39 (87%), hematologic in 36 (80%) and gastrointestinal in 36 (80%) patients. Acute anterior uveitis was diagnosed in nine (20%) patients. Two patients presented with clinical findings of deep neck infection such as fever, neck pain, trismus, swelling and induration on the cervical lymph node. One patient presented with Henoch-Schonlein purpura-like eruption. Coronary artery dilatation was detected in five (11%) patients. For treatment of MIS-C, intravenous immunoglobulin was used in 44 (98%) patients, methylprednisolone in 27 (60%) and anakinra in 9 (20%) patients. The median duration of hospitalisation was nine days. All patients recovered.
Conclusions: Children with MIS-C might have variable clinical presentations. Acute anterior uveitis might be a prominent presentation of MIS-C and require ophthalmological examination. It is essential to make patient-based decisions and apply a stepwise approach for the treatment of this life-threatening disease.
Keywords: SARS-CoV-2; acute anterior uveitis; children; multisystem inflammatory syndrome associated with COVID-19.
. 2021 Aug 3.
doi: 10.1111/jpc.15674. Online ahead of print.
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus-2 pandemic in Turkey: A single-centre experience
Zeynep Savas Sen[SUP] 1 [/SUP], Gonul Tanir[SUP] 1 [/SUP], Ruveyda Gumuser Cinni[SUP] 1 [/SUP], Mutlu Uysal Yazici[SUP] 2 [/SUP], Tamer Yoldas[SUP] 3 [/SUP], Zeynelabidin Ozturk[SUP] 2 [/SUP], Mete Han Kizilkaya[SUP] 3 [/SUP], Suna Ozdem[SUP] 1 [/SUP], Rumeysa Yalcinkaya[SUP] 1 [/SUP], Caner Ozturk[SUP] 4 [/SUP], Aslihan Yuce Sezen[SUP] 4 [/SUP], Semanur Ozdel[SUP] 5 [/SUP], Betul Emine Derinkuyu[SUP] 6 [/SUP], Meltem Polat[SUP] 1 [/SUP], Fatma Nur Oz[SUP] 1 [/SUP]
Affiliations
- PMID: 34343373
- DOI: 10.1111/jpc.15674
Abstract
Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may result in a life-threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS-C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS-C.
Methods: We performed a retrospective study of patients with MIS-C managed between August 2020 and March 2021 at Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital in Turkey.
Results: A total of 45 patients (23 male, 51%) with a median age of 8.7 years (interquartile range: 5.6-11.7 years) were enrolled to study. The SARS-CoV-2 serology was positive in 43 (95%) patients. Organ-system involvement included the dermatologic in 41 (91%), cardiovascular in 39 (87%), hematologic in 36 (80%) and gastrointestinal in 36 (80%) patients. Acute anterior uveitis was diagnosed in nine (20%) patients. Two patients presented with clinical findings of deep neck infection such as fever, neck pain, trismus, swelling and induration on the cervical lymph node. One patient presented with Henoch-Schonlein purpura-like eruption. Coronary artery dilatation was detected in five (11%) patients. For treatment of MIS-C, intravenous immunoglobulin was used in 44 (98%) patients, methylprednisolone in 27 (60%) and anakinra in 9 (20%) patients. The median duration of hospitalisation was nine days. All patients recovered.
Conclusions: Children with MIS-C might have variable clinical presentations. Acute anterior uveitis might be a prominent presentation of MIS-C and require ophthalmological examination. It is essential to make patient-based decisions and apply a stepwise approach for the treatment of this life-threatening disease.
Keywords: SARS-CoV-2; acute anterior uveitis; children; multisystem inflammatory syndrome associated with COVID-19.