tetano
Editor, Senior Moderator
J Obstet Gynaecol Res
. 2021 Nov 23.
doi: 10.1111/jog.15105. Online ahead of print.
Obstetric and neonatal outcomes after SARS-CoV-2 infection in the first trimester of pregnancy: A prospective comparative study
Stefano Cosma[SUP] 1 [/SUP], Andrea Roberto Carosso[SUP] 1 [/SUP], Jessica Cusato[SUP] 2 [/SUP], Fulvio Borella[SUP] 1 [/SUP], Luca Bertero[SUP] 3 [/SUP], Marialuisa Bovetti[SUP] 1 [/SUP], Federica Bevilacqua[SUP] 1 [/SUP], Giulio Mengozzi[SUP] 4 [/SUP], Raffaela Mazzone[SUP] 4 [/SUP], Valeria Ghisetti[SUP] 5 [/SUP], Giovanni Di Perri[SUP] 6 [/SUP], Chiara Benedetto[SUP] 1 [/SUP]
Affiliations
Abstract
Objective(s): This prospective observational cohort study aimed to evaluate whether women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the first trimester of pregnancy are at higher risk of adverse obstetric and neonatal outcomes compared to negative patients.
Study design: Seromolecular testing for SARS-CoV-2 was performed at 12, 16, 21 weeks, and at delivery; the cohort was then subdivided into a first-trimester SARS-CoV-2-positive (case) group and a SARS-CoV-2-negative (control) group. The primary outcome was a composite adverse obstetric outcome, defined as the presence of either abortion, preterm delivery, preterm prelabor rupture of membranes, preeclampsia, intrauterine growth restriction, stillbirth; and a composite measure of adverse neonatal events, including either 1- and 5-min Apgar score ≤ 7, neonatal intensive care unit admission and congenital birth defects. Maternal symptoms and antibody titer were secondarily assessed.
Results: A total of 17 of 164 women tested positive for SARS-CoV-2 (10.3%) in the first trimester. One SARS-CoV-2-positive patient who gave birth at another hospital was excluded. Composite adverse obstetric outcome was observed in 6.2% (1/16) SARS-CoV-2-positive and 10.5% (11/105) SARS-CoV-2-negative women; composite adverse neonatal outcome in 12.5% (2/16) and 7.6% (8/105), respectively. In the newborns of women who had developed IgG antibodies, the same antibodies were detected in arterial cord blood and the nasopharyngeal swab tested negative for SARS-CoV-2. No maternal pneumonia or hospital admission due to coronavirus disease-19 were recorded.
Conclusion: Asymptomatic or mildly symptomatic women during the first trimester of pregnancy did not experience significantly more adverse events than SARS-CoV-2-negative women.
Keywords: COVID-19; SARS-CoV-2; outcome; pregnancy; vertical transmission.
. 2021 Nov 23.
doi: 10.1111/jog.15105. Online ahead of print.
Obstetric and neonatal outcomes after SARS-CoV-2 infection in the first trimester of pregnancy: A prospective comparative study
Stefano Cosma[SUP] 1 [/SUP], Andrea Roberto Carosso[SUP] 1 [/SUP], Jessica Cusato[SUP] 2 [/SUP], Fulvio Borella[SUP] 1 [/SUP], Luca Bertero[SUP] 3 [/SUP], Marialuisa Bovetti[SUP] 1 [/SUP], Federica Bevilacqua[SUP] 1 [/SUP], Giulio Mengozzi[SUP] 4 [/SUP], Raffaela Mazzone[SUP] 4 [/SUP], Valeria Ghisetti[SUP] 5 [/SUP], Giovanni Di Perri[SUP] 6 [/SUP], Chiara Benedetto[SUP] 1 [/SUP]
Affiliations
- PMID: 34814234
- DOI: 10.1111/jog.15105
Abstract
Objective(s): This prospective observational cohort study aimed to evaluate whether women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the first trimester of pregnancy are at higher risk of adverse obstetric and neonatal outcomes compared to negative patients.
Study design: Seromolecular testing for SARS-CoV-2 was performed at 12, 16, 21 weeks, and at delivery; the cohort was then subdivided into a first-trimester SARS-CoV-2-positive (case) group and a SARS-CoV-2-negative (control) group. The primary outcome was a composite adverse obstetric outcome, defined as the presence of either abortion, preterm delivery, preterm prelabor rupture of membranes, preeclampsia, intrauterine growth restriction, stillbirth; and a composite measure of adverse neonatal events, including either 1- and 5-min Apgar score ≤ 7, neonatal intensive care unit admission and congenital birth defects. Maternal symptoms and antibody titer were secondarily assessed.
Results: A total of 17 of 164 women tested positive for SARS-CoV-2 (10.3%) in the first trimester. One SARS-CoV-2-positive patient who gave birth at another hospital was excluded. Composite adverse obstetric outcome was observed in 6.2% (1/16) SARS-CoV-2-positive and 10.5% (11/105) SARS-CoV-2-negative women; composite adverse neonatal outcome in 12.5% (2/16) and 7.6% (8/105), respectively. In the newborns of women who had developed IgG antibodies, the same antibodies were detected in arterial cord blood and the nasopharyngeal swab tested negative for SARS-CoV-2. No maternal pneumonia or hospital admission due to coronavirus disease-19 were recorded.
Conclusion: Asymptomatic or mildly symptomatic women during the first trimester of pregnancy did not experience significantly more adverse events than SARS-CoV-2-negative women.
Keywords: COVID-19; SARS-CoV-2; outcome; pregnancy; vertical transmission.