tetano
Editor, Senior Moderator
J Neurovirol
. 2021 Jan 25.
doi: 10.1007/s13365-020-00941-1. Online ahead of print.
Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature
Maziar Emamikhah[SUP] 1 [/SUP], Mansoureh Babadi[SUP] 2 [/SUP], Mehrnoush Mehrabani[SUP] 3 [/SUP], Mehdi Jalili[SUP] 2 [/SUP], Maryam Pouranian[SUP] 4 [/SUP], Peyman Daraie[SUP] 5 [/SUP], Fahimeh Mohaghegh[SUP] 1 [/SUP], Sharmin Aghavali[SUP] 1 [/SUP], Maryam Zaribafian[SUP] 6 [/SUP], Mohammad Rohani[SUP] 7 8 [/SUP]
Affiliations
Abstract
Opsoclonus-myoclonus-ataxia syndrome is a heterogeneous constellation of symptoms ranging from full combination of these three neurological findings to varying degrees of isolated individual sign. Since the emergence of coronavirus disease 2019 (COVID-19), neurological symptoms, syndromes, and complications associated with this multi-organ viral infection have been reported and the various aspects of neurological involvement are increasingly uncovered. As a neuro-inflammatory disorder, one would expect to observe opsoclonus-myoclonus syndrome after a prevalent viral infection in a pandemic scale, as it has been the case for many other neuro-inflammatory syndromes. We report seven cases of opsoclonus-myoclonus syndrome presumably parainfectious in nature and discuss their phenomenology, their possible pathophysiological relationship to COVID-19, and diagnostic and treatment strategy in each case. Finally, we review the relevant data in the literature regarding the opsoclonus-myoclonus syndrome and possible similar cases associated with COVID-19 and its diagnostic importance for clinicians in various fields of medicine encountering COVID-19 patients and its complications.
Keywords: COVID-19; Myoclonus; Opsoclonus; Parainfectious; SARS-CoV-2.
. 2021 Jan 25.
doi: 10.1007/s13365-020-00941-1. Online ahead of print.
Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature
Maziar Emamikhah[SUP] 1 [/SUP], Mansoureh Babadi[SUP] 2 [/SUP], Mehrnoush Mehrabani[SUP] 3 [/SUP], Mehdi Jalili[SUP] 2 [/SUP], Maryam Pouranian[SUP] 4 [/SUP], Peyman Daraie[SUP] 5 [/SUP], Fahimeh Mohaghegh[SUP] 1 [/SUP], Sharmin Aghavali[SUP] 1 [/SUP], Maryam Zaribafian[SUP] 6 [/SUP], Mohammad Rohani[SUP] 7 8 [/SUP]
Affiliations
- PMID: 33492608
- DOI: 10.1007/s13365-020-00941-1
Abstract
Opsoclonus-myoclonus-ataxia syndrome is a heterogeneous constellation of symptoms ranging from full combination of these three neurological findings to varying degrees of isolated individual sign. Since the emergence of coronavirus disease 2019 (COVID-19), neurological symptoms, syndromes, and complications associated with this multi-organ viral infection have been reported and the various aspects of neurological involvement are increasingly uncovered. As a neuro-inflammatory disorder, one would expect to observe opsoclonus-myoclonus syndrome after a prevalent viral infection in a pandemic scale, as it has been the case for many other neuro-inflammatory syndromes. We report seven cases of opsoclonus-myoclonus syndrome presumably parainfectious in nature and discuss their phenomenology, their possible pathophysiological relationship to COVID-19, and diagnostic and treatment strategy in each case. Finally, we review the relevant data in the literature regarding the opsoclonus-myoclonus syndrome and possible similar cases associated with COVID-19 and its diagnostic importance for clinicians in various fields of medicine encountering COVID-19 patients and its complications.
Keywords: COVID-19; Myoclonus; Opsoclonus; Parainfectious; SARS-CoV-2.