tetano
Editor, Senior Moderator
J Neurovirol
. 2021 Mar 1.
doi: 10.1007/s13365-020-00938-w. Online ahead of print.
Detection of SARS-coronavirus-2 in the central nervous system of patients with severe acute respiratory syndrome and seizures
Fariborz Rezaeitalab[SUP] 1 2 [/SUP], Saeid Amel Jamehdar[SUP] 3 [/SUP], Ali Sepehrinezhad[SUP] 1 4 [/SUP], Azra Rashidnezhad[SUP] 2 [/SUP], Fereydoun Moradi[SUP] 2 [/SUP], Fateme Sadat Esmaeli Fard[SUP] 2 [/SUP], Sepideh Hasanzadeh[SUP] 3 [/SUP], Mohammad Etezad Razavi[SUP] 5 [/SUP], Ali Gorji[SUP] 1 6 7 8 9 10 [/SUP], Sajad Sahab Negah[SUP] 11 12 13 [/SUP]
Affiliations
Abstract
This study was designed to evaluate whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can directly target the central nervous system (CNS). We present four patients suffering from the loss of consciousness and seizure during the clinical course of COVID-19 infection. In addition to positive nasopharyngeal swab tests, SARS-CoV-2 has been detected in their cerebrospinal fluid. This report indicates the neuroinvasive potential of SARS-CoV-2, suggesting the ability of this virus to spread from the respiratory tract to the CNS.
Keywords: Brain; CNS; Convulsion; Neuroinvasion; SARS-CoV-2.
. 2021 Mar 1.
doi: 10.1007/s13365-020-00938-w. Online ahead of print.
Detection of SARS-coronavirus-2 in the central nervous system of patients with severe acute respiratory syndrome and seizures
Fariborz Rezaeitalab[SUP] 1 2 [/SUP], Saeid Amel Jamehdar[SUP] 3 [/SUP], Ali Sepehrinezhad[SUP] 1 4 [/SUP], Azra Rashidnezhad[SUP] 2 [/SUP], Fereydoun Moradi[SUP] 2 [/SUP], Fateme Sadat Esmaeli Fard[SUP] 2 [/SUP], Sepideh Hasanzadeh[SUP] 3 [/SUP], Mohammad Etezad Razavi[SUP] 5 [/SUP], Ali Gorji[SUP] 1 6 7 8 9 10 [/SUP], Sajad Sahab Negah[SUP] 11 12 13 [/SUP]
Affiliations
- PMID: 33650073
- DOI: 10.1007/s13365-020-00938-w
Abstract
This study was designed to evaluate whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can directly target the central nervous system (CNS). We present four patients suffering from the loss of consciousness and seizure during the clinical course of COVID-19 infection. In addition to positive nasopharyngeal swab tests, SARS-CoV-2 has been detected in their cerebrospinal fluid. This report indicates the neuroinvasive potential of SARS-CoV-2, suggesting the ability of this virus to spread from the respiratory tract to the CNS.
Keywords: Brain; CNS; Convulsion; Neuroinvasion; SARS-CoV-2.