tetano
Editor, Senior Moderator
J Neurol Sci
. 2023 Oct 11:456:120834.
doi: 10.1016/j.jns.2023.120834. Online ahead of print. No association between SARS-CoV-2 vaccination and ischaemic stroke or high-risk transient ischaemic attack
Silvia Komarek[SUP] 1 [/SUP], Benjamin Dejakum[SUP] 1 [/SUP], Kurt Moelgg[SUP] 1 [/SUP], Christian Boehme[SUP] 2 [/SUP], Anel Karisik[SUP] 1 [/SUP], Thomas Toell[SUP] 2 [/SUP], Stefan Kiechl[SUP] 1 [/SUP], Michael Knoflach[SUP] 1 [/SUP], Raimund Pechlaner[SUP] 2 [/SUP], Lukas Mayer-Suess[SUP] 3 [/SUP]
Affiliations
Background: Initiation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) vaccinations aroused scepticism within the general-public about risks including stroke. Our aim was to explore temporal associations between vaccination and cerebrovascular events through an analysis of a prospective large-scale cohort of consecutive stroke and high-risk TIA (transitory ischaemic attack) patients.
Methods: We prospectively recruited a cohort of consecutive ischaemic stroke and high-risk TIA (ABCD2-Score ≥ 4) patients treated at the Innsbruck University Hospital (STROKE-CARD Registry Study, NCT04582825) from December 2020 until February 2022. SARS-CoV-2 vaccination status and the time of administration was ascertained by electronic health-data. A Cox model with vaccination status as time-dependent co-variable was employed to examine its association with ischaemic events.
Results: Data on 572 participants were available with 355 (62.1%) vaccinated against SARS-CoV-2 before suffering cerebral ischaemia. In our cohort, no temporal association between vaccination and cerebrovascular event was detected (HR 1.06 [0.85-1.34; p = 0.60]) and this also applies to TIA (HR [0.82 0.37-1.85; p = 0.64]) or minor stroke (HR 1.18 [0.89-1.56; p = 0.26]) and subgroups defined by sex and age. Neither vector-based (HR 1.11 [0.79-1.56; p = 0.55]) nor mRNA-based (HR 1.06 [0.84-1.34; p = 0.61]) vaccinations were associated with the occurrence of cerebral ischaemia.
Conclusion: Among patients with stroke or high-risk TIA, SARS-CoV-2 vaccination was not associated with cerebral ischaemia.
Keywords: Cerebral ischemia; Ischemic stroke; Sars-cov-2 vaccine; Transient ischemic attack.
. 2023 Oct 11:456:120834.
doi: 10.1016/j.jns.2023.120834. Online ahead of print. No association between SARS-CoV-2 vaccination and ischaemic stroke or high-risk transient ischaemic attack
Silvia Komarek[SUP] 1 [/SUP], Benjamin Dejakum[SUP] 1 [/SUP], Kurt Moelgg[SUP] 1 [/SUP], Christian Boehme[SUP] 2 [/SUP], Anel Karisik[SUP] 1 [/SUP], Thomas Toell[SUP] 2 [/SUP], Stefan Kiechl[SUP] 1 [/SUP], Michael Knoflach[SUP] 1 [/SUP], Raimund Pechlaner[SUP] 2 [/SUP], Lukas Mayer-Suess[SUP] 3 [/SUP]
Affiliations
- PMID: 38134562
- DOI: 10.1016/j.jns.2023.120834
Background: Initiation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) vaccinations aroused scepticism within the general-public about risks including stroke. Our aim was to explore temporal associations between vaccination and cerebrovascular events through an analysis of a prospective large-scale cohort of consecutive stroke and high-risk TIA (transitory ischaemic attack) patients.
Methods: We prospectively recruited a cohort of consecutive ischaemic stroke and high-risk TIA (ABCD2-Score ≥ 4) patients treated at the Innsbruck University Hospital (STROKE-CARD Registry Study, NCT04582825) from December 2020 until February 2022. SARS-CoV-2 vaccination status and the time of administration was ascertained by electronic health-data. A Cox model with vaccination status as time-dependent co-variable was employed to examine its association with ischaemic events.
Results: Data on 572 participants were available with 355 (62.1%) vaccinated against SARS-CoV-2 before suffering cerebral ischaemia. In our cohort, no temporal association between vaccination and cerebrovascular event was detected (HR 1.06 [0.85-1.34; p = 0.60]) and this also applies to TIA (HR [0.82 0.37-1.85; p = 0.64]) or minor stroke (HR 1.18 [0.89-1.56; p = 0.26]) and subgroups defined by sex and age. Neither vector-based (HR 1.11 [0.79-1.56; p = 0.55]) nor mRNA-based (HR 1.06 [0.84-1.34; p = 0.61]) vaccinations were associated with the occurrence of cerebral ischaemia.
Conclusion: Among patients with stroke or high-risk TIA, SARS-CoV-2 vaccination was not associated with cerebral ischaemia.
Keywords: Cerebral ischemia; Ischemic stroke; Sars-cov-2 vaccine; Transient ischemic attack.