tetano
Editor, Senior Moderator
J Neurol
. 2021 Apr 29.
doi: 10.1007/s00415-021-10562-1. Online ahead of print.
Intraluminal carotid thrombosis and acute ischemic stroke associated with COVID-19
Diaa Hamouda[SUP] 1 [/SUP], Dinesh V Jillella[SUP] 2 [/SUP], Nirav Bhatt[SUP] 1 [/SUP], Sitara Koneru[SUP] 1 [/SUP], Michael R Frankel[SUP] 1 [/SUP], Raul G Nogueira[SUP] 1 [/SUP]
Affiliations
Abstract
COVID-19 (Coronavirus disease 2019) caused by SARS-CoV-2 has a diverse constellation of neurological manifestations that include encephalopathy, stroke, Guillain-Barr? syndrome, myelitis, and encephalitis. Intraluminal carotid thrombi (ILT) are infrequent lesions seen in only 1.6% of patients with acute ischemic stroke. Underlying atherosclerosis is the most common lesion associated with ILT formation. However, with COVID-19, we have encountered ILT in patients without significant atherosclerotic disease. The endothelial inflammation and hypercoagulable state associated with COVID-19 pose a risk of arterial and venous thromboembolism and could have contributed to this presentation although the exact pathophysiology and optimal treatment of ILT in COVID-19 remain elusive. Herein, we present a series of ischemic stroke patients with carotid ILT in the setting of a recent SARS-CoV-2 infection.
Keywords: Acute stroke; COVID-19; Carotid thrombus; Intraluminal thrombus; Ischemic stroke.
. 2021 Apr 29.
doi: 10.1007/s00415-021-10562-1. Online ahead of print.
Intraluminal carotid thrombosis and acute ischemic stroke associated with COVID-19
Diaa Hamouda[SUP] 1 [/SUP], Dinesh V Jillella[SUP] 2 [/SUP], Nirav Bhatt[SUP] 1 [/SUP], Sitara Koneru[SUP] 1 [/SUP], Michael R Frankel[SUP] 1 [/SUP], Raul G Nogueira[SUP] 1 [/SUP]
Affiliations
- PMID: 33914141
- DOI: 10.1007/s00415-021-10562-1
Abstract
COVID-19 (Coronavirus disease 2019) caused by SARS-CoV-2 has a diverse constellation of neurological manifestations that include encephalopathy, stroke, Guillain-Barr? syndrome, myelitis, and encephalitis. Intraluminal carotid thrombi (ILT) are infrequent lesions seen in only 1.6% of patients with acute ischemic stroke. Underlying atherosclerosis is the most common lesion associated with ILT formation. However, with COVID-19, we have encountered ILT in patients without significant atherosclerotic disease. The endothelial inflammation and hypercoagulable state associated with COVID-19 pose a risk of arterial and venous thromboembolism and could have contributed to this presentation although the exact pathophysiology and optimal treatment of ILT in COVID-19 remain elusive. Herein, we present a series of ischemic stroke patients with carotid ILT in the setting of a recent SARS-CoV-2 infection.
Keywords: Acute stroke; COVID-19; Carotid thrombus; Intraluminal thrombus; Ischemic stroke.