tetano
Editor, Senior Moderator
J Neurol
. 2020 May 30;1-4.
doi: 10.1007/s00415-020-09951-9. Online ahead of print.
COVID-19-associated Acute Disseminated Encephalomyelitis (ADEM)
Timothy Parsons[SUP] 1 2 [/SUP], Sarah Banks[SUP] 3 4 [/SUP], Chay Bae[SUP] 4 [/SUP], Joel Gelber[SUP] 3 [/SUP], Hussein Alahmadi[SUP] 3 [/SUP], Matthew Tichauer[SUP] 3 4 [/SUP]
Affiliations
Abstract
A 51-year-old woman with COVID-19 infection developed coma and an impaired oculocephalic response to one side. MRI of the brain demonstrated acute multifocal demyelinating lesions, and CSF testing did not identify a direct cerebral infection. High-dose steroids followed by a course of IVIG was administered, and the patient regained consciousness over the course of several weeks. As more patients reach the weeks after initial infection with COVID-19, acute disseminated encephalomyelitis should be considered a potentially treatable cause of profound encephalopathy or multifocal neurological deficits.
Keywords: ADEM; COVID-19; Coronavirus; Demyelinating disease; Post-infectious.
. 2020 May 30;1-4.
doi: 10.1007/s00415-020-09951-9. Online ahead of print.
COVID-19-associated Acute Disseminated Encephalomyelitis (ADEM)
Timothy Parsons[SUP] 1 2 [/SUP], Sarah Banks[SUP] 3 4 [/SUP], Chay Bae[SUP] 4 [/SUP], Joel Gelber[SUP] 3 [/SUP], Hussein Alahmadi[SUP] 3 [/SUP], Matthew Tichauer[SUP] 3 4 [/SUP]
Affiliations
- PMID: 32474657
- PMCID: PMC7260459
- DOI: 10.1007/s00415-020-09951-9
Abstract
A 51-year-old woman with COVID-19 infection developed coma and an impaired oculocephalic response to one side. MRI of the brain demonstrated acute multifocal demyelinating lesions, and CSF testing did not identify a direct cerebral infection. High-dose steroids followed by a course of IVIG was administered, and the patient regained consciousness over the course of several weeks. As more patients reach the weeks after initial infection with COVID-19, acute disseminated encephalomyelitis should be considered a potentially treatable cause of profound encephalopathy or multifocal neurological deficits.
Keywords: ADEM; COVID-19; Coronavirus; Demyelinating disease; Post-infectious.