tetano
Editor, Senior Moderator
J Neuroimmunol
. 2021 Apr 18;355:577577.
doi: 10.1016/j.jneuroim.2021.577577. Online ahead of print.
Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review
Abu Baker Sheikh[SUP] 1 [/SUP], Prabal Kumar Chourasia[SUP] 2 [/SUP], Nismat Javed[SUP] 3 [/SUP], Mehul Kumar Chourasia[SUP] 4 [/SUP], Sajid S Suriya[SUP] 5 [/SUP], Shubhra Upadhyay[SUP] 6 [/SUP], Fatima Ijaz[SUP] 6 [/SUP], Suman Pal[SUP] 6 [/SUP], Narges Moghimi[SUP] 5 [/SUP], Rahul Shekhar[SUP] 6 [/SUP]
Affiliations
Abstract
Objective: The systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.
Methods: After protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann-Whitney U test, were used. P < 0.05 was considered significant.
Results: We identified 64 relevant articles. The mean age of the patients was 56 ? 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05).
Conclusions: GBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.
Keywords: Acute inflammatory demyelinating polyneuropathy; COVID-19; Guillain-Barre syndrome; Miller-Fisher syndrome.
. 2021 Apr 18;355:577577.
doi: 10.1016/j.jneuroim.2021.577577. Online ahead of print.
Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review
Abu Baker Sheikh[SUP] 1 [/SUP], Prabal Kumar Chourasia[SUP] 2 [/SUP], Nismat Javed[SUP] 3 [/SUP], Mehul Kumar Chourasia[SUP] 4 [/SUP], Sajid S Suriya[SUP] 5 [/SUP], Shubhra Upadhyay[SUP] 6 [/SUP], Fatima Ijaz[SUP] 6 [/SUP], Suman Pal[SUP] 6 [/SUP], Narges Moghimi[SUP] 5 [/SUP], Rahul Shekhar[SUP] 6 [/SUP]
Affiliations
- PMID: 33895700
- DOI: 10.1016/j.jneuroim.2021.577577
Abstract
Objective: The systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.
Methods: After protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann-Whitney U test, were used. P < 0.05 was considered significant.
Results: We identified 64 relevant articles. The mean age of the patients was 56 ? 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05).
Conclusions: GBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.
Keywords: Acute inflammatory demyelinating polyneuropathy; COVID-19; Guillain-Barre syndrome; Miller-Fisher syndrome.