tetano
Editor, Senior Moderator
J Neuroimmunol
. 2022 Oct 28;373:577994.
doi: 10.1016/j.jneuroim.2022.577994. Online ahead of print.
Aquaporin-4 IgG neuromyelitis optica spectrum disorder onset after Covid-19 vaccination: Systematic review
Ehab Harahsheh[SUP] 1 [/SUP], Marcus Callister[SUP] 2 [/SUP], Shemonti Hasan[SUP] 2 [/SUP], David Gritsch[SUP] 3 [/SUP], Cristina Valencia-Sanchez[SUP] 2 [/SUP]
Affiliations
Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is rarely reported following Coronavirus disease 2019 (COVID-19) vaccination. We identified 16 cases of new onset NMOSD with positive aquaporin-4 IgG (AQP4-IgG) following COVID-19 vaccination. Transverse myelitis was the most common clinical presentation (75%). Most patients received high dose steroids for acute treatment and maintenance therapy was started in 12 patients (75%). Twelve patients (75%) had improvement of their symptoms at the time of discharge or follow-up. The included cases share similar epidemiology and natural course to non-vaccine related cases. Clinicians should be aware of possible post-vaccination NMOSD to help with earlier diagnosis and treatment.
Keywords: Aquaporin-4; Neuromyelitis optica spectrum disorders; Vaccination.
. 2022 Oct 28;373:577994.
doi: 10.1016/j.jneuroim.2022.577994. Online ahead of print.
Aquaporin-4 IgG neuromyelitis optica spectrum disorder onset after Covid-19 vaccination: Systematic review
Ehab Harahsheh[SUP] 1 [/SUP], Marcus Callister[SUP] 2 [/SUP], Shemonti Hasan[SUP] 2 [/SUP], David Gritsch[SUP] 3 [/SUP], Cristina Valencia-Sanchez[SUP] 2 [/SUP]
Affiliations
- PMID: 36332464
- DOI: 10.1016/j.jneuroim.2022.577994
Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is rarely reported following Coronavirus disease 2019 (COVID-19) vaccination. We identified 16 cases of new onset NMOSD with positive aquaporin-4 IgG (AQP4-IgG) following COVID-19 vaccination. Transverse myelitis was the most common clinical presentation (75%). Most patients received high dose steroids for acute treatment and maintenance therapy was started in 12 patients (75%). Twelve patients (75%) had improvement of their symptoms at the time of discharge or follow-up. The included cases share similar epidemiology and natural course to non-vaccine related cases. Clinicians should be aware of possible post-vaccination NMOSD to help with earlier diagnosis and treatment.
Keywords: Aquaporin-4; Neuromyelitis optica spectrum disorders; Vaccination.