tetano
Editor, Senior Moderator
J Neonatal Perinatal Med
. 2022 Aug 17.
doi: 10.3233/NPM-221002. Online ahead of print.
Case report: Fatal COVID-19 in a neonate after probable late intrauterine transmission
T G Boyce[SUP] 1 [/SUP], E M Chacko[SUP] 2 [/SUP], M A Mascola[SUP] 3 [/SUP], A Joshi[SUP] 4 [/SUP], C G Verwoerd[SUP] 4 [/SUP], A A Winder[SUP] 4 [/SUP], S J Hale[SUP] 5 [/SUP]
Affiliations
Abstract
We report the case of a 35-week gestation infant girl born by emergent cesarean section for fetal distress in a woman with recent coronavirus disease 2019 (COVID-19). Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using polymerase chain reaction (PCR) on the infant at 24 and 48 hours of life were negative. However, at 72 hours of life, the infant's respiratory status worsened, and a repeat SARS-CoV-2 PCR was positive. The infant developed leukopenia, thrombocytopenia, and progressive respiratory failure, and died on the ninth day of life. Pathologic examination of the placenta revealed findings consistent with COVID-19 placentitis, and SARS-CoV-2 RNA staining was positive, suggesting intrauterine transmission of the infection.
Keywords: Coronavirus disease 2019; SARS-CoV-2; death; histology; newborn; placenta.
. 2022 Aug 17.
doi: 10.3233/NPM-221002. Online ahead of print.
Case report: Fatal COVID-19 in a neonate after probable late intrauterine transmission
T G Boyce[SUP] 1 [/SUP], E M Chacko[SUP] 2 [/SUP], M A Mascola[SUP] 3 [/SUP], A Joshi[SUP] 4 [/SUP], C G Verwoerd[SUP] 4 [/SUP], A A Winder[SUP] 4 [/SUP], S J Hale[SUP] 5 [/SUP]
Affiliations
- PMID: 35988227
- DOI: 10.3233/NPM-221002
Abstract
We report the case of a 35-week gestation infant girl born by emergent cesarean section for fetal distress in a woman with recent coronavirus disease 2019 (COVID-19). Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using polymerase chain reaction (PCR) on the infant at 24 and 48 hours of life were negative. However, at 72 hours of life, the infant's respiratory status worsened, and a repeat SARS-CoV-2 PCR was positive. The infant developed leukopenia, thrombocytopenia, and progressive respiratory failure, and died on the ninth day of life. Pathologic examination of the placenta revealed findings consistent with COVID-19 placentitis, and SARS-CoV-2 RNA staining was positive, suggesting intrauterine transmission of the infection.
Keywords: Coronavirus disease 2019; SARS-CoV-2; death; histology; newborn; placenta.