tetano
Editor, Senior Moderator
J Natl Med Assoc
. 2021 Sep 16;S0027-9684(21)00208-X.
doi: 10.1016/j.jnma.2021.09.003. Online ahead of print.
Association between race and risk of ICU mortality in mechanically ventilated COVID-19 patients at a safety net hospital
Titilope Olanipekun[SUP] 1 [/SUP], Temidayo Abe[SUP] 2 [/SUP], Timothy Sobukonla[SUP] 2 [/SUP], Jothika Tamizharasu[SUP] 2 [/SUP], Linda Gamo[SUP] 2 [/SUP], Nelson T Kuete[SUP] 2 [/SUP], Nicolas Bakinde[SUP] 2 [/SUP], Gloria Westney[SUP] 3 [/SUP], Richard H Snyder[SUP] 3 [/SUP]
Affiliations
Abstract
Purpose: To determine racial differences in intensive care unit (ICU) mortality outcomes among mechanically ventilated patients with severe coronavirus disease 2019 (COVID-19) infection in a safety net hospital.
Methods: We retrospectively analyzed a cohort of patients ≥ 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease associated respiratory failure who were treated with invasive mechanical ventilation and admitted to the ICU from May 1, 2020 - July 30 -2020 at Grady Memorial Hospital, Atlanta, Georgia - a safety net hospital. We evaluated the association between mortality and demographics, co-morbidities, inpatient laboratory, and radiological parameters.
Results: Among 181 critically ill mechanically ventilated African American patients treated at a safety net hospital, the mortality rate was 33%. On stratified analysis by race (Table 2), mortality rates were significantly higher in African Americans (39%) and Hispanics (26.3%), compared to Whites (18.9%). On multivariate regression, African Americans were 3 times more likely to die in the ICU compared to Whites (OR 3.1 95% CI 1.6 -5.5). Likewise, the likelihood of mortality was higher in Hispanics compared to Whites (OR 1.3 95% CI 1.0 -3.9).
Conclusions: Our study demonstrated a high ICU mortality rate in a cohort of mechanically ventilated patients with severe COVID-19 infection treated at a safety net hospital. African Americans and Hispanics had significantly higher risks of ICU mortality compared to Whites. These study findings further elucidate the disproportionately higher burden of COVID-19 infection in African Americans and Hispanics.
Keywords: African Americans; COVID-19; Critical care; Mechanical ventilation; Mortality.
. 2021 Sep 16;S0027-9684(21)00208-X.
doi: 10.1016/j.jnma.2021.09.003. Online ahead of print.
Association between race and risk of ICU mortality in mechanically ventilated COVID-19 patients at a safety net hospital
Titilope Olanipekun[SUP] 1 [/SUP], Temidayo Abe[SUP] 2 [/SUP], Timothy Sobukonla[SUP] 2 [/SUP], Jothika Tamizharasu[SUP] 2 [/SUP], Linda Gamo[SUP] 2 [/SUP], Nelson T Kuete[SUP] 2 [/SUP], Nicolas Bakinde[SUP] 2 [/SUP], Gloria Westney[SUP] 3 [/SUP], Richard H Snyder[SUP] 3 [/SUP]
Affiliations
- PMID: 34615602
- DOI: 10.1016/j.jnma.2021.09.003
Abstract
Purpose: To determine racial differences in intensive care unit (ICU) mortality outcomes among mechanically ventilated patients with severe coronavirus disease 2019 (COVID-19) infection in a safety net hospital.
Methods: We retrospectively analyzed a cohort of patients ≥ 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease associated respiratory failure who were treated with invasive mechanical ventilation and admitted to the ICU from May 1, 2020 - July 30 -2020 at Grady Memorial Hospital, Atlanta, Georgia - a safety net hospital. We evaluated the association between mortality and demographics, co-morbidities, inpatient laboratory, and radiological parameters.
Results: Among 181 critically ill mechanically ventilated African American patients treated at a safety net hospital, the mortality rate was 33%. On stratified analysis by race (Table 2), mortality rates were significantly higher in African Americans (39%) and Hispanics (26.3%), compared to Whites (18.9%). On multivariate regression, African Americans were 3 times more likely to die in the ICU compared to Whites (OR 3.1 95% CI 1.6 -5.5). Likewise, the likelihood of mortality was higher in Hispanics compared to Whites (OR 1.3 95% CI 1.0 -3.9).
Conclusions: Our study demonstrated a high ICU mortality rate in a cohort of mechanically ventilated patients with severe COVID-19 infection treated at a safety net hospital. African Americans and Hispanics had significantly higher risks of ICU mortality compared to Whites. These study findings further elucidate the disproportionately higher burden of COVID-19 infection in African Americans and Hispanics.
Keywords: African Americans; COVID-19; Critical care; Mechanical ventilation; Mortality.