tetano
Editor, Senior Moderator
J Mol Cell Cardiol
. 2020 Dec 26;S0022-2828(20)30349-7.
doi: 10.1016/j.yjmcc.2020.12.009. Online ahead of print.
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19
Walid Hamouche[SUP] 1 [/SUP], Malik Bisserier[SUP] 2 [/SUP], Agnieszka Brojakowska[SUP] 2 [/SUP], Abrisham Eskandari[SUP] 2 [/SUP], Kenneth Fish[SUP] 2 [/SUP], David A Goukassian[SUP] 2 [/SUP], Lahouaria Hadri[SUP] 3 [/SUP]
Affiliations
Abstract
The first confirmed case of novel Coronavirus Disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of November 24, 2020, close to 12.2 million cases of COVID-19 was confirmed in the US, with over 255,958 deaths. The rapid transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), its unusual and divergent presentation has strengthened the status of COVID-19 as a major public health threat. In this review, we aim to 1- discuss the epidemiological data from various COVID-19 patient cohorts around the world and the USA as well the associated risk factors; 2- summarize the pathophysiology of SARS-CoV-2 infection and the underlying molecular mechanisms for the respiratory and cardiovascular manifestations; 3- highlight the potential treatments and vaccines as well as current clinical trials for COVID-19.
Keywords: COVID-19; Clinical features; Physiopathology; Treatment.
. 2020 Dec 26;S0022-2828(20)30349-7.
doi: 10.1016/j.yjmcc.2020.12.009. Online ahead of print.
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19
Walid Hamouche[SUP] 1 [/SUP], Malik Bisserier[SUP] 2 [/SUP], Agnieszka Brojakowska[SUP] 2 [/SUP], Abrisham Eskandari[SUP] 2 [/SUP], Kenneth Fish[SUP] 2 [/SUP], David A Goukassian[SUP] 2 [/SUP], Lahouaria Hadri[SUP] 3 [/SUP]
Affiliations
- PMID: 33373644
- DOI: 10.1016/j.yjmcc.2020.12.009
Abstract
The first confirmed case of novel Coronavirus Disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of November 24, 2020, close to 12.2 million cases of COVID-19 was confirmed in the US, with over 255,958 deaths. The rapid transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), its unusual and divergent presentation has strengthened the status of COVID-19 as a major public health threat. In this review, we aim to 1- discuss the epidemiological data from various COVID-19 patient cohorts around the world and the USA as well the associated risk factors; 2- summarize the pathophysiology of SARS-CoV-2 infection and the underlying molecular mechanisms for the respiratory and cardiovascular manifestations; 3- highlight the potential treatments and vaccines as well as current clinical trials for COVID-19.
Keywords: COVID-19; Clinical features; Physiopathology; Treatment.