tetano
Editor, Senior Moderator
J Mol Cell Biol
. 2021 Mar 9;mjab016.
doi: 10.1093/jmcb/mjab016. Online ahead of print.
What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology
Dania Altulea[SUP] 1 [/SUP], Sjors Maassen[SUP] 1 [/SUP], Maksim V Baranov[SUP] 1 [/SUP], Geert van den Bogaart[SUP] 1 2 [/SUP]
Affiliations
Abstract
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
Keywords: COVID-19; SARS-CoV-2; chloroquine; coronavirus; hydroxychloroquine.
. 2021 Mar 9;mjab016.
doi: 10.1093/jmcb/mjab016. Online ahead of print.
What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology
Dania Altulea[SUP] 1 [/SUP], Sjors Maassen[SUP] 1 [/SUP], Maksim V Baranov[SUP] 1 [/SUP], Geert van den Bogaart[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33693723
- DOI: 10.1093/jmcb/mjab016
Abstract
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
Keywords: COVID-19; SARS-CoV-2; chloroquine; coronavirus; hydroxychloroquine.