tetano
Editor, Senior Moderator
J Mol Cell Biol
. 2020 Dec 30;mjaa070.
doi: 10.1093/jmcb/mjaa070. Online ahead of print.
The development of neutralizing antibodies against SARS-CoV-2 and their common features
Liu Daisy Liu[SUP] 1 [/SUP], Chaoyang Lian[SUP] 2 [/SUP], Leng-Siew Yeap[SUP] 2 [/SUP], Fei-Long Meng[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide severe coronavirus disease 2019 (COVID-19) pandemic since December 2019. There is a great demand for effective therapies for the prevention and treatment of COVID-19. Developing therapeutic neutralizing antibodies (NAbs), which could block viral infection, issuch a promising approach, as NAbs have been successfully applied to the treatment of other viral infections. The recent advances of antibody technology have greatly accelerated the discovery of SARS-CoV-2 NAbs, and many of which are now actively tested in clinical trials. Here, we review the approaches applied for SARS-CoV-2 NAb development, and discuss the emerging technologies underlining the antibody discovery. We further summarize the common features of these antibodies including the shared neutralizing epitopes and sequence features.
Keywords: COVID-19; RBD; SARS-CoV-2; epitope; neutralizing antibody.
. 2020 Dec 30;mjaa070.
doi: 10.1093/jmcb/mjaa070. Online ahead of print.
The development of neutralizing antibodies against SARS-CoV-2 and their common features
Liu Daisy Liu[SUP] 1 [/SUP], Chaoyang Lian[SUP] 2 [/SUP], Leng-Siew Yeap[SUP] 2 [/SUP], Fei-Long Meng[SUP] 1 [/SUP]
Affiliations
- PMID: 33377928
- DOI: 10.1093/jmcb/mjaa070
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide severe coronavirus disease 2019 (COVID-19) pandemic since December 2019. There is a great demand for effective therapies for the prevention and treatment of COVID-19. Developing therapeutic neutralizing antibodies (NAbs), which could block viral infection, issuch a promising approach, as NAbs have been successfully applied to the treatment of other viral infections. The recent advances of antibody technology have greatly accelerated the discovery of SARS-CoV-2 NAbs, and many of which are now actively tested in clinical trials. Here, we review the approaches applied for SARS-CoV-2 NAb development, and discuss the emerging technologies underlining the antibody discovery. We further summarize the common features of these antibodies including the shared neutralizing epitopes and sequence features.
Keywords: COVID-19; RBD; SARS-CoV-2; epitope; neutralizing antibody.