tetano
Editor, Senior Moderator
J Med Virol
. 2022 May 5.
doi: 10.1002/jmv.27833. Online ahead of print.
Virus-virus interactions of febrile respiratory syndrome among patients in China based on surveillance data from February 2011 to December 2020
Yucen Dai[SUP] 1 [/SUP], Jiao Zhong[SUP] 2 3 [/SUP], Yajia Lan[SUP] 2 [/SUP]
Affiliations
Abstract
Background: The burden of acute respiratory infections is still considerable, and virus-virus interactions may affect their epidemics, but previous evidence is inconclusive.
Objective: To quantitatively investigate the interactions among respiratory viruses at both the population and individual levels.
Methods: Cases tested for influenza virus (IV), respiratory syncytial virus (RSV), human parainfluenza virus (PIV), human Adenovirus (AdV), human coronavirus (CoV), human bocavirus (BoV) and rhinoviruses (RV) were collected from the pathogen surveillance for febrile respiratory syndrome (FRS) in China from February 2011 to December 2020. We used spearman's rank correlation coefficients and binary logistic regression models to analyze the interactions between any two of the viruses at the population and individual levels, respectively.
Results: Among 120,237 cases, 4.5% were co-infected with two or more viruses. Correlation coefficients showed 7 virus pairs were positively correlated, namely: IV and RSV, PIV and AdV, PIV and CoV, PIV and BoV, PIV and RV, AdV and BoV, CoV and RV. Regression models showed except for the negative interaction between IV and RV (OR=0.70, 95%CI: 0.61-0.81), all other virus pairs had positive interactions.
Conclusion: Most of the respiratory viruses interact positively, while IV and RV interact negatively. This article is protected by copyright. All rights reserved.
Keywords: Acute febrile respiratory syndrome; Epidemiology; Interaction; Pathogen surveillance; Respiratory virus.
. 2022 May 5.
doi: 10.1002/jmv.27833. Online ahead of print.
Virus-virus interactions of febrile respiratory syndrome among patients in China based on surveillance data from February 2011 to December 2020
Yucen Dai[SUP] 1 [/SUP], Jiao Zhong[SUP] 2 3 [/SUP], Yajia Lan[SUP] 2 [/SUP]
Affiliations
- PMID: 35514049
- DOI: 10.1002/jmv.27833
Abstract
Background: The burden of acute respiratory infections is still considerable, and virus-virus interactions may affect their epidemics, but previous evidence is inconclusive.
Objective: To quantitatively investigate the interactions among respiratory viruses at both the population and individual levels.
Methods: Cases tested for influenza virus (IV), respiratory syncytial virus (RSV), human parainfluenza virus (PIV), human Adenovirus (AdV), human coronavirus (CoV), human bocavirus (BoV) and rhinoviruses (RV) were collected from the pathogen surveillance for febrile respiratory syndrome (FRS) in China from February 2011 to December 2020. We used spearman's rank correlation coefficients and binary logistic regression models to analyze the interactions between any two of the viruses at the population and individual levels, respectively.
Results: Among 120,237 cases, 4.5% were co-infected with two or more viruses. Correlation coefficients showed 7 virus pairs were positively correlated, namely: IV and RSV, PIV and AdV, PIV and CoV, PIV and BoV, PIV and RV, AdV and BoV, CoV and RV. Regression models showed except for the negative interaction between IV and RV (OR=0.70, 95%CI: 0.61-0.81), all other virus pairs had positive interactions.
Conclusion: Most of the respiratory viruses interact positively, while IV and RV interact negatively. This article is protected by copyright. All rights reserved.
Keywords: Acute febrile respiratory syndrome; Epidemiology; Interaction; Pathogen surveillance; Respiratory virus.