tetano
Editor, Senior Moderator
J Med Virol
. 2021 Mar 23.
doi: 10.1002/jmv.26954. Online ahead of print.
Use of Chlorhexidine to Eradicate Oropharyngeal SARS-CoV-2 in COVID-19 Patients
Y Hanna Huang[SUP] 1 [/SUP], Jong T Huang[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: As public distribution of a vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underway, prevention of coronavirus disease 2019 (COVID-19) relies on minimizing spread. In this study, chlorhexidine gluconate was investigated as a topical antimicrobial agent against SARS-CoV-2.
Methods: This was a randomized, prospective cohort study using chlorhexidine as an oral rinse and posterior oropharyngeal spray in hospitalized COVID-19 patients. The primary outcome was presence or absence of laboratory-confirmed SARS-CoV-2 in the oral and oropharyngeal cavities after four days of chlorhexidine use and standard of care (study group) or standard of care only (control group).
Results: SARS-CoV-2 was eliminated from the oropharynx in 62.1% of patients who used chlorhexidine as an oral rinse, versus 5.5% of the control group patients. In patients who used a combination of oral rinse and oropharyngeal spray, 86.0% eliminated oropharyngeal SARS-CoV-2, versus 6.3% of control patients.
Conclusions: Chlorhexidine is a simple and safe addition to current COVID-19 prevention guidelines and may play a significant role in reducing disease spread. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; antiviral agents; coronavirus; disinfectants; dissemination; epidemiology; shedding.
. 2021 Mar 23.
doi: 10.1002/jmv.26954. Online ahead of print.
Use of Chlorhexidine to Eradicate Oropharyngeal SARS-CoV-2 in COVID-19 Patients
Y Hanna Huang[SUP] 1 [/SUP], Jong T Huang[SUP] 2 [/SUP]
Affiliations
- PMID: 33755218
- DOI: 10.1002/jmv.26954
Abstract
Objective: As public distribution of a vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underway, prevention of coronavirus disease 2019 (COVID-19) relies on minimizing spread. In this study, chlorhexidine gluconate was investigated as a topical antimicrobial agent against SARS-CoV-2.
Methods: This was a randomized, prospective cohort study using chlorhexidine as an oral rinse and posterior oropharyngeal spray in hospitalized COVID-19 patients. The primary outcome was presence or absence of laboratory-confirmed SARS-CoV-2 in the oral and oropharyngeal cavities after four days of chlorhexidine use and standard of care (study group) or standard of care only (control group).
Results: SARS-CoV-2 was eliminated from the oropharynx in 62.1% of patients who used chlorhexidine as an oral rinse, versus 5.5% of the control group patients. In patients who used a combination of oral rinse and oropharyngeal spray, 86.0% eliminated oropharyngeal SARS-CoV-2, versus 6.3% of control patients.
Conclusions: Chlorhexidine is a simple and safe addition to current COVID-19 prevention guidelines and may play a significant role in reducing disease spread. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; antiviral agents; coronavirus; disinfectants; dissemination; epidemiology; shedding.