tetano
Editor, Senior Moderator
J Med Virol
. 2024 Aug;96(8):e29877.
doi: 10.1002/jmv.29877. Understanding the landscape of the SARS-CoV-2-specific T cells post-omicron surge
Akshay Binayke[SUP] 1 2 3 [/SUP], Aymaan Zaheer[SUP] 1 [/SUP], Siddhesh Vishwakarma[SUP] 1 [/SUP], Priyanka Sharma[SUP] 1 [/SUP], Jyotsna Dandotiya[SUP] 2 [/SUP], Sreevatsan Raghavan[SUP] 4 [/SUP], Mudita Gosain[SUP] 4 [/SUP], Savita Singh[SUP] 4 [/SUP], Souvick Chattopadhyay[SUP] 4 [/SUP], Jyotsana Kaushal[SUP] 1 [/SUP], Upasna Madan[SUP] 2 [/SUP], Pallavi Kshetrapal[SUP] 4 [/SUP], Gaurav Batra[SUP] 4 [/SUP], Nitya Wadhwa[SUP] 4 [/SUP], Anil Kumar Pandey[SUP] 5 [/SUP], Shinjini Bhatnagar[SUP] 4 [/SUP], Pramod Kumar Garg[SUP] 4 6 [/SUP], Amit Awasthi[SUP] 1 2 [/SUP]
Affiliations
Emerging evidence shows increased humoral response post-omicron surge, but research on T cell responses is limited. This study investigated the durability, magnitude, and breadth of SARS-CoV-2-spike-specific T cell responses in 216 two-dose vaccinated individuals pre- and post-omicron surge. Post-surge samples showed enhanced T cell responses, indicating widespread asymptomatic exposure to omicron. Further analysis of 105 individuals with multiple exposures to SARS-CoV-2 through boosters or infections showed that post-omicron, two-dose vaccinated individuals had T cell responses comparable to those of COVID-19 convalescents or boosted individuals. Additionally, we report cross-reactive T cell responses against omicron sub-variants, including BA2.86, remained strong, with preserved frequencies of spike-specific stem-cell-like memory T cells. In silico prediction indicates that mutated epitopes of JN.1 and KP.2 retain over 95.6% of their HLA binding capability. Overall, our data suggests that T cell responses are sustained, enhanced, and cross-reactive against emerging SARS-CoV-2 variants following symptomatic or asymptomatic omicron infection.
Keywords: COVID‐19; KP.2; SARS‐CoV‐2 T cell; omicron surge; seronegative.
. 2024 Aug;96(8):e29877.
doi: 10.1002/jmv.29877. Understanding the landscape of the SARS-CoV-2-specific T cells post-omicron surge
Akshay Binayke[SUP] 1 2 3 [/SUP], Aymaan Zaheer[SUP] 1 [/SUP], Siddhesh Vishwakarma[SUP] 1 [/SUP], Priyanka Sharma[SUP] 1 [/SUP], Jyotsna Dandotiya[SUP] 2 [/SUP], Sreevatsan Raghavan[SUP] 4 [/SUP], Mudita Gosain[SUP] 4 [/SUP], Savita Singh[SUP] 4 [/SUP], Souvick Chattopadhyay[SUP] 4 [/SUP], Jyotsana Kaushal[SUP] 1 [/SUP], Upasna Madan[SUP] 2 [/SUP], Pallavi Kshetrapal[SUP] 4 [/SUP], Gaurav Batra[SUP] 4 [/SUP], Nitya Wadhwa[SUP] 4 [/SUP], Anil Kumar Pandey[SUP] 5 [/SUP], Shinjini Bhatnagar[SUP] 4 [/SUP], Pramod Kumar Garg[SUP] 4 6 [/SUP], Amit Awasthi[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39169721
- DOI: 10.1002/jmv.29877
Emerging evidence shows increased humoral response post-omicron surge, but research on T cell responses is limited. This study investigated the durability, magnitude, and breadth of SARS-CoV-2-spike-specific T cell responses in 216 two-dose vaccinated individuals pre- and post-omicron surge. Post-surge samples showed enhanced T cell responses, indicating widespread asymptomatic exposure to omicron. Further analysis of 105 individuals with multiple exposures to SARS-CoV-2 through boosters or infections showed that post-omicron, two-dose vaccinated individuals had T cell responses comparable to those of COVID-19 convalescents or boosted individuals. Additionally, we report cross-reactive T cell responses against omicron sub-variants, including BA2.86, remained strong, with preserved frequencies of spike-specific stem-cell-like memory T cells. In silico prediction indicates that mutated epitopes of JN.1 and KP.2 retain over 95.6% of their HLA binding capability. Overall, our data suggests that T cell responses are sustained, enhanced, and cross-reactive against emerging SARS-CoV-2 variants following symptomatic or asymptomatic omicron infection.
Keywords: COVID‐19; KP.2; SARS‐CoV‐2 T cell; omicron surge; seronegative.