tetano
Editor, Senior Moderator
J Med Virol
. 2022 Nov 11.
doi: 10.1002/jmv.28296. Online ahead of print.
Transplacental transmission of SARS-CoV-2 immunoglobulin G antibody to infants from maternal COVID-19 vaccine immunization before pregnancy
Yuting Yang[SUP] 1 [/SUP], Huiwu Xing[SUP] 1 [/SUP], Yao Zhao[SUP] 1 [/SUP]
Affiliations
Abstract
Background & aim: Coronavirus disease 2019 (COVID-19) vaccine generates functional antibodies in maternal circulation that are detectable in infants, while the information is restricted to the usage of COVID-19 vaccine during pregnancy. In this study, we aimed to evaluate the effect of maternal COVID-19 vaccines before pregnancy.
Method: Infants were included from mothers with no inactivated COVID-19 vaccine, 1-dose, 2-dose and 3-dose before pregnancy, and SARS-CoV-2 IgG antibodies were tested. Comparative analysis was done between the groups.
Results: A total of 130 infants were enrolled in the study. Significantly higher levels of SARS-CoV-2 IgG antibodies in infants born to mothers with 3-dose COVID-19 vaccine before pregnancy compared with 1-dose and 2-dose groups (p<0.0001). The levels of antibodies decreased significantly with age in infants born to mothers with the 3-dose COVID-19 vaccine before pregnancy (r=-0.338, p=0.035), and it was still higher than that 2-dose COVID-19 vaccine group.
Conclusion: The maternal SARS-CoV-2 antibodies produced from the inactivated COVID-19 vaccine before pregnancy can be transferred to newborns via the placenta. Maternal immunization with 3-dose of the COVID-19 vaccine before pregnancy could be more beneficial for both mothers and infants. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus; Disease control; SARS coronavirus; Vaccines/Vaccine strains; Virus classification; Virusclassification.
. 2022 Nov 11.
doi: 10.1002/jmv.28296. Online ahead of print.
Transplacental transmission of SARS-CoV-2 immunoglobulin G antibody to infants from maternal COVID-19 vaccine immunization before pregnancy
Yuting Yang[SUP] 1 [/SUP], Huiwu Xing[SUP] 1 [/SUP], Yao Zhao[SUP] 1 [/SUP]
Affiliations
- PMID: 36367230
- DOI: 10.1002/jmv.28296
Abstract
Background & aim: Coronavirus disease 2019 (COVID-19) vaccine generates functional antibodies in maternal circulation that are detectable in infants, while the information is restricted to the usage of COVID-19 vaccine during pregnancy. In this study, we aimed to evaluate the effect of maternal COVID-19 vaccines before pregnancy.
Method: Infants were included from mothers with no inactivated COVID-19 vaccine, 1-dose, 2-dose and 3-dose before pregnancy, and SARS-CoV-2 IgG antibodies were tested. Comparative analysis was done between the groups.
Results: A total of 130 infants were enrolled in the study. Significantly higher levels of SARS-CoV-2 IgG antibodies in infants born to mothers with 3-dose COVID-19 vaccine before pregnancy compared with 1-dose and 2-dose groups (p<0.0001). The levels of antibodies decreased significantly with age in infants born to mothers with the 3-dose COVID-19 vaccine before pregnancy (r=-0.338, p=0.035), and it was still higher than that 2-dose COVID-19 vaccine group.
Conclusion: The maternal SARS-CoV-2 antibodies produced from the inactivated COVID-19 vaccine before pregnancy can be transferred to newborns via the placenta. Maternal immunization with 3-dose of the COVID-19 vaccine before pregnancy could be more beneficial for both mothers and infants. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus; Disease control; SARS coronavirus; Vaccines/Vaccine strains; Virus classification; Virusclassification.