tetano
Editor, Senior Moderator
J Med Virol
. 2022 Aug 9.
doi: 10.1002/jmv.28060. Online ahead of print.
Tracing the origin of Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2): A systematic review and narrative synthesis
Nagendra Thakur[SUP] 1 [/SUP], Sayak Das[SUP] 1 [/SUP], Swatantra Kumar[SUP] 2 [/SUP], Vimal K Maurya[SUP] 2 [/SUP], Kuldeep Dhama[SUP] 3 [/SUP], Janusz T Paweska[SUP] 4 [/SUP], Ahmed S Abdel-Moneim[SUP] 5 [/SUP], Amita Jain[SUP] 2 [/SUP], Anil K Tripathi[SUP] 2 [/SUP], Bipin Puri[SUP] 2 [/SUP], Shailendra K Saxena[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: To trace and understand the origin of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through various available literatures and accessible databases.
Background: While the world enters the third year of the coronavirus disease 2019 pandemic and the health and socio-economic impacts continue to mount, the origin and mechanisms of spill-over of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into humans, remain elusive.
Methods: A systematic review of the literature is being showcased that integrated information obtained through manual searches, digital database (PubMed, CINAHL and MEDLINE) searches and searches from legitimate publications (1966-2022).
Results: Our systematic analysis proposes three postulated hypotheses concerning the origin of the SARS-CoV-2, which include Zoonotic origin (Z), Laboratory origin (L) and obscure origin (O). Despite the fact that the zoonotic origin for SARS-CoV-2 has not been conclusively identified to date, our data suggest a zoonotic origin, in contrast to some alternative concepts, including the probability of a laboratory incident or leak.
Conclusions: Our data exhibits that Zoonotic origin (Z) has higher evidence-based support as compared to Laboratory origin (L). Importantly, based on all the studies included, we generated the forest plot with 95% confidence intervals (CIs) of the risk ratio estimates. Our analysis showed that the black diamond supports the zoonotic origin of SARS/SARS-CoV-2 in the included studies. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; laboratory incidence; origin; zoonotic.
. 2022 Aug 9.
doi: 10.1002/jmv.28060. Online ahead of print.
Tracing the origin of Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2): A systematic review and narrative synthesis
Nagendra Thakur[SUP] 1 [/SUP], Sayak Das[SUP] 1 [/SUP], Swatantra Kumar[SUP] 2 [/SUP], Vimal K Maurya[SUP] 2 [/SUP], Kuldeep Dhama[SUP] 3 [/SUP], Janusz T Paweska[SUP] 4 [/SUP], Ahmed S Abdel-Moneim[SUP] 5 [/SUP], Amita Jain[SUP] 2 [/SUP], Anil K Tripathi[SUP] 2 [/SUP], Bipin Puri[SUP] 2 [/SUP], Shailendra K Saxena[SUP] 2 [/SUP]
Affiliations
- PMID: 35945190
- DOI: 10.1002/jmv.28060
Abstract
Objective: To trace and understand the origin of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through various available literatures and accessible databases.
Background: While the world enters the third year of the coronavirus disease 2019 pandemic and the health and socio-economic impacts continue to mount, the origin and mechanisms of spill-over of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into humans, remain elusive.
Methods: A systematic review of the literature is being showcased that integrated information obtained through manual searches, digital database (PubMed, CINAHL and MEDLINE) searches and searches from legitimate publications (1966-2022).
Results: Our systematic analysis proposes three postulated hypotheses concerning the origin of the SARS-CoV-2, which include Zoonotic origin (Z), Laboratory origin (L) and obscure origin (O). Despite the fact that the zoonotic origin for SARS-CoV-2 has not been conclusively identified to date, our data suggest a zoonotic origin, in contrast to some alternative concepts, including the probability of a laboratory incident or leak.
Conclusions: Our data exhibits that Zoonotic origin (Z) has higher evidence-based support as compared to Laboratory origin (L). Importantly, based on all the studies included, we generated the forest plot with 95% confidence intervals (CIs) of the risk ratio estimates. Our analysis showed that the black diamond supports the zoonotic origin of SARS/SARS-CoV-2 in the included studies. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; laboratory incidence; origin; zoonotic.