tetano
Editor, Senior Moderator
J Med Virol
. 2020 Aug 8.
doi: 10.1002/jmv.26409. Online ahead of print.
The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate
Lutfiye Karcioglu Batur[SUP] 1 [/SUP], Nezih Hekim[SUP] 1 [/SUP]
Affiliations
Abstract
Since December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has given rise to emerging respiratory infections with a pandemical diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. The main goal of this study was to evaluate if there is any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID-19 and its mortality rates caused among populations of ten countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype (p < 0.05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations (p < 0.05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech and Turkey. The variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588. This article is protected by copyright. All rights reserved.
Keywords: coronavirus disease 2019; polymorphism; rs4588; rs7041; vitamin D binding protein.
. 2020 Aug 8.
doi: 10.1002/jmv.26409. Online ahead of print.
The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate
Lutfiye Karcioglu Batur[SUP] 1 [/SUP], Nezih Hekim[SUP] 1 [/SUP]
Affiliations
- PMID: 32770768
- DOI: 10.1002/jmv.26409
Abstract
Since December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has given rise to emerging respiratory infections with a pandemical diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. The main goal of this study was to evaluate if there is any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID-19 and its mortality rates caused among populations of ten countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype (p < 0.05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations (p < 0.05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech and Turkey. The variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588. This article is protected by copyright. All rights reserved.
Keywords: coronavirus disease 2019; polymorphism; rs4588; rs7041; vitamin D binding protein.