tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jul 13.
doi: 10.1002/jmv.27996. Online ahead of print.
The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis
Masoud Rahmati[SUP] 1 [/SUP], Maryam Keshvari[SUP] 1 [/SUP], Shahrzad Mirnasuri[SUP] 2 [/SUP], Dong Keon Yon[SUP] 3 [/SUP], Seung Won Lee[SUP] 4 5 [/SUP], Jae Il Shin[SUP] 6 [/SUP], Lee Smith[SUP] 7 [/SUP]
Affiliations
Abstract
Objective: Viral infections may increase the risk of developing type 1 diabetes (T1D), and recent reports suggest that Coronavirus Disease 2019 (COVID-19) might have increased incidence of pediatric T1D and/or diabetic ketoacidosis (DKA). Therefore, this meta-analysis aims to estimate the risk of global pediatric new-onset T1D, DKA, and severe DKA before and after the COVID-19 pandemic.
Methods: A systematic search of MEDLINE/PubMed, CINAHL, Scopus, and EMBASE was conducted for articles published up to March 2022. A random-effects meta-analysis was performed to compare the relative risk of T1D and DKA among pediatric patients with T1D between the COVID-19 pre-pandemic and pandemic periods. We also compared glucose and HbA1c values in children who were newly diagnosed with T1D before and after the COVID-19 pandemic.
Results: The global incidence rate of T1D in the 2019 period was 19.73 per 100,000 children and 32.39 per 100,000 in the 2020 period. Compared with pre-COVID-19 pandemic, the number of worldwide pediatric new-onset T1D, DKA, and severe DKA during the first year of the COVID-19 pandemic increased by 9.5%, 25%, and 19.5%, respectively. Compared with pre-COVID-19 pandemic levels, the median glucose, and HbA1c values in newly diagnosed T1D children after the COVID-19 pandemic increased by 6.43% and 6.42%, respectively.
Conclusion: The COVID-19 pandemic has significantly increased the risk of global pediatric new-onset T1D, DKA, and severe DKA. Moreover, higher glucose and HbA1c values in newly diagnosed T1D children after the COVID-19 pandemic mandates targeted measures to raise public and physician awareness. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Exercise; Meta-analysis.; Physical activity.
. 2022 Jul 13.
doi: 10.1002/jmv.27996. Online ahead of print.
The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis
Masoud Rahmati[SUP] 1 [/SUP], Maryam Keshvari[SUP] 1 [/SUP], Shahrzad Mirnasuri[SUP] 2 [/SUP], Dong Keon Yon[SUP] 3 [/SUP], Seung Won Lee[SUP] 4 5 [/SUP], Jae Il Shin[SUP] 6 [/SUP], Lee Smith[SUP] 7 [/SUP]
Affiliations
- PMID: 35831242
- DOI: 10.1002/jmv.27996
Abstract
Objective: Viral infections may increase the risk of developing type 1 diabetes (T1D), and recent reports suggest that Coronavirus Disease 2019 (COVID-19) might have increased incidence of pediatric T1D and/or diabetic ketoacidosis (DKA). Therefore, this meta-analysis aims to estimate the risk of global pediatric new-onset T1D, DKA, and severe DKA before and after the COVID-19 pandemic.
Methods: A systematic search of MEDLINE/PubMed, CINAHL, Scopus, and EMBASE was conducted for articles published up to March 2022. A random-effects meta-analysis was performed to compare the relative risk of T1D and DKA among pediatric patients with T1D between the COVID-19 pre-pandemic and pandemic periods. We also compared glucose and HbA1c values in children who were newly diagnosed with T1D before and after the COVID-19 pandemic.
Results: The global incidence rate of T1D in the 2019 period was 19.73 per 100,000 children and 32.39 per 100,000 in the 2020 period. Compared with pre-COVID-19 pandemic, the number of worldwide pediatric new-onset T1D, DKA, and severe DKA during the first year of the COVID-19 pandemic increased by 9.5%, 25%, and 19.5%, respectively. Compared with pre-COVID-19 pandemic levels, the median glucose, and HbA1c values in newly diagnosed T1D children after the COVID-19 pandemic increased by 6.43% and 6.42%, respectively.
Conclusion: The COVID-19 pandemic has significantly increased the risk of global pediatric new-onset T1D, DKA, and severe DKA. Moreover, higher glucose and HbA1c values in newly diagnosed T1D children after the COVID-19 pandemic mandates targeted measures to raise public and physician awareness. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Exercise; Meta-analysis.; Physical activity.