tetano
Editor, Senior Moderator
J Med Virol
. 2023 Sep;95(9):e29113.
doi: 10.1002/jmv.29113. The binding profile of SARS-CoV-2 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion
Yan Zhan[SUP] 1 2 3 4 [/SUP], Ling Ye[SUP] 5 [/SUP], Qianying Ouyang[SUP] 1 2 3 4 [/SUP], Jiye Yin[SUP] 1 2 3 4 [/SUP], Jiajia Cui[SUP] 6 [/SUP], Ke Liu[SUP] 1 2 3 4 [/SUP], Chengxian Guo[SUP] 5 [/SUP], Haibo Zhang[SUP] 7 [/SUP], Jingbo Zhai[SUP] 8 [/SUP], Chunfu Zheng[SUP] 9 [/SUP], Aoxiang Guo[SUP] 10 11 [/SUP], Bao Sun[SUP] 12 [/SUP]
Affiliations
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), astonished the world and led to millions of deaths. Due to viral new mutations and immune evasion, SARS-CoV-2 ranked first in transmission and influence. The binding affinity of human leukocyte antigen (HLA) polymorphisms to SARS-CoV-2 might be related to immune escape, but the mechanisms remained unclear. In this study, we obtained the binding affinity of SARS-CoV-2 strains with different HLA proteins and identified 31 risk alleles. Subsequent structural predictions identified 10 active binding sites in these HLA proteins that may promote immune evasion. Particularly, we also found that the weak binding ability with HLA class I polymorphisms could contribute to the immune evasion of Omicron. These findings suggest important implications for preventing the immune evasion of SARS-CoV-2 and providing new insights for the vaccine design.
Keywords: COVID-19; HLA genetics; SARS-CoV-2; immune evasion; viral infection.
. 2023 Sep;95(9):e29113.
doi: 10.1002/jmv.29113. The binding profile of SARS-CoV-2 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion
Yan Zhan[SUP] 1 2 3 4 [/SUP], Ling Ye[SUP] 5 [/SUP], Qianying Ouyang[SUP] 1 2 3 4 [/SUP], Jiye Yin[SUP] 1 2 3 4 [/SUP], Jiajia Cui[SUP] 6 [/SUP], Ke Liu[SUP] 1 2 3 4 [/SUP], Chengxian Guo[SUP] 5 [/SUP], Haibo Zhang[SUP] 7 [/SUP], Jingbo Zhai[SUP] 8 [/SUP], Chunfu Zheng[SUP] 9 [/SUP], Aoxiang Guo[SUP] 10 11 [/SUP], Bao Sun[SUP] 12 [/SUP]
Affiliations
- PMID: 37750416
- DOI: 10.1002/jmv.29113
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), astonished the world and led to millions of deaths. Due to viral new mutations and immune evasion, SARS-CoV-2 ranked first in transmission and influence. The binding affinity of human leukocyte antigen (HLA) polymorphisms to SARS-CoV-2 might be related to immune escape, but the mechanisms remained unclear. In this study, we obtained the binding affinity of SARS-CoV-2 strains with different HLA proteins and identified 31 risk alleles. Subsequent structural predictions identified 10 active binding sites in these HLA proteins that may promote immune evasion. Particularly, we also found that the weak binding ability with HLA class I polymorphisms could contribute to the immune evasion of Omicron. These findings suggest important implications for preventing the immune evasion of SARS-CoV-2 and providing new insights for the vaccine design.
Keywords: COVID-19; HLA genetics; SARS-CoV-2; immune evasion; viral infection.