tetano
Editor, Senior Moderator
J Med Virol. 2020 Apr 24.
doi: 10.1002/jmv.25936. Online ahead of print.
SARS-CoV-2 Can Be Detected in Urine, Blood, Anal Swabs and Oropharyngeal Swabs Specimens
Liang Peng[SUP] 1 2 [/SUP], Jing Liu[SUP] 1 2 [/SUP], Wenxiong Xu[SUP] 1 2 [/SUP], Qiumin Luo[SUP] 1 2 [/SUP], Dabiao Chen[SUP] 1 2 [/SUP], Ziying Lei[SUP] 1 2 [/SUP], Zhanlian Huang[SUP] 1 2 [/SUP], Xuejun Li[SUP] 1 2 [/SUP], Keji Deng[SUP] 3 [/SUP], Bingliang Lin[SUP] 1 2 [/SUP], Zhiliang Gao[SUP] 1 2 [/SUP]
Affiliations
Abstract
Purpose: The purpose of this study was to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings.
Methods: Patients with confirmed SARS-CoV-2 infections were included in this study. Patients' demographic and clinical data were recorded. Quantitative real-time PCR was used to detect SARS-CoV-2 RNA in urine and blood specimens, and anal and oropharyngeal swabs. The study is registered at ClinicalTrials.gov (No. NCT04279782, February 19, 2020).
Results: SARS-CoV-2 RNA was present in all 4 specimen types, though not all specimen types were positive simultaneously. The presence of viral RNA was not necessarily predictive of clinical symptoms, e.g., the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms.
Conclusions: SARS-CoV-2 can infect multiple systems, including the urinary tract. Testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; prognosis; real-time polymerase chain reaction; specimens; urine.
doi: 10.1002/jmv.25936. Online ahead of print.
SARS-CoV-2 Can Be Detected in Urine, Blood, Anal Swabs and Oropharyngeal Swabs Specimens
Liang Peng[SUP] 1 2 [/SUP], Jing Liu[SUP] 1 2 [/SUP], Wenxiong Xu[SUP] 1 2 [/SUP], Qiumin Luo[SUP] 1 2 [/SUP], Dabiao Chen[SUP] 1 2 [/SUP], Ziying Lei[SUP] 1 2 [/SUP], Zhanlian Huang[SUP] 1 2 [/SUP], Xuejun Li[SUP] 1 2 [/SUP], Keji Deng[SUP] 3 [/SUP], Bingliang Lin[SUP] 1 2 [/SUP], Zhiliang Gao[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32330305
- DOI: 10.1002/jmv.25936
Abstract
Purpose: The purpose of this study was to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings.
Methods: Patients with confirmed SARS-CoV-2 infections were included in this study. Patients' demographic and clinical data were recorded. Quantitative real-time PCR was used to detect SARS-CoV-2 RNA in urine and blood specimens, and anal and oropharyngeal swabs. The study is registered at ClinicalTrials.gov (No. NCT04279782, February 19, 2020).
Results: SARS-CoV-2 RNA was present in all 4 specimen types, though not all specimen types were positive simultaneously. The presence of viral RNA was not necessarily predictive of clinical symptoms, e.g., the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms.
Conclusions: SARS-CoV-2 can infect multiple systems, including the urinary tract. Testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; prognosis; real-time polymerase chain reaction; specimens; urine.