tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jul 10.
doi: 10.1002/jmv.27992. Online ahead of print.
Safety and Immunogenicity of COVID-19 Vaccination in Patients with Hepatocellular Carcinoma (CHESS-NMCID 2101): A Multicenter Prospective Study
Xiaolong Qi[SUP] 1 [/SUP], Jitao Wang[SUP] 1 2 [/SUP], Qiran Zhang[SUP] 3 [/SUP], Jingwen Ai[SUP] 3 [/SUP], Chuan Liu[SUP] 1 [/SUP], Qianqian Li[SUP] 4 [/SUP], Ye Gu[SUP] 5 [/SUP], Jiaojian Lv[SUP] 6 [/SUP], Yifei Huang[SUP] 1 [/SUP], Yanna Liu[SUP] 7 [/SUP], Dan Xu[SUP] 1 [/SUP], Shubo Chen[SUP] 2 [/SUP], Dengxiang Liu[SUP] 2 [/SUP], Jinlong Li[SUP] 2 [/SUP], Huiling Xiang[SUP] 4 [/SUP], Jing Liang[SUP] 4 [/SUP], Li Bian[SUP] 5 [/SUP], Zhen Zhang[SUP] 5 [/SUP], Luxiang Liu[SUP] 7 [/SUP], Xuying Zhang[SUP] 8 [/SUP], Wei Qin[SUP] 9 [/SUP], Xiaodong Wang[SUP] 9 [/SUP], Zhiyun Hou[SUP] 10 [/SUP], Nina Zhang[SUP] 10 [/SUP], Aiguo Zhang[SUP] 10 [/SUP], Hongmei Zu[SUP] 11 [/SUP], Yun Wang[SUP] 11 [/SUP], Zhaolan Yan[SUP] 11 [/SUP], Du Xiufang[SUP] 12 [/SUP], Aifang Hou[SUP] 12 [/SUP], Jiansong Ji[SUP] 13 [/SUP], Jie Yang[SUP] 13 [/SUP], Jiansheng Huang[SUP] 13 [/SUP], Zhongwei Zhao[SUP] 13 [/SUP], Shengqiang Zou[SUP] 14 [/SUP], Hailei Ji[SUP] 14 [/SUP], Guohong Ge[SUP] 14 [/SUP], Qing-Lei Zeng[SUP] 15 [/SUP], Wenhong Zhang[SUP] 3 [/SUP]
Affiliations
Abstract
Data on safety and immunogenicity of coronavirus disease 2019 (COVID-19) vaccinations in hepatocellular carcinoma (HCC) patients are limited. In this multicenter prospective study, HCC patients received 2 doses of inactivated whole-virion COVID-19 vaccines. The safety and neutralizing antibody were monitored. Totally, 74 patients were enrolled from 10 centers in China, and 37 (50.0%), 25 (33.8%), and 12 (16.2%) received the CoronaVac, BBIBP-CorV, and WIBP-CorV, respectively. The vaccines were well tolerated, the injection site pain (6.8% [5/74]) and anorexia (2.7% [2/74]) were the most frequently local and systemic adverse events. The median level of neutralizing antibody was 13.5 (interquartile range [IQR]: 6.9-23.2) AU/mL at 45 (IQR: 19-72) days after the second dose of vaccinations, and 60.8% (45/74) of patients had positive neutralizing antibody. Additionally, lower gamma-glutamyl transpeptidase level was related to positive neutralizing antibody (odds ratio = 1.022 [1.003-1.049], p = 0.049). In conclusion, this study found that inactivated COVID-19 vaccinations are safe and the immunogenicity is acceptable or hyporesponsive in patients with HCC. Given that the potential benefits may outweigh the risks and the continuing emergences of novel severe acute respiratory syndrome coronavirus 2 variants, we suggest HCC patients to be vaccinated against COVID-19. Future validation studies are warranted. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus disease 2019; Hepatocellular carcinoma; Immunogenicity; Inactivated Vaccine; Safety..
. 2022 Jul 10.
doi: 10.1002/jmv.27992. Online ahead of print.
Safety and Immunogenicity of COVID-19 Vaccination in Patients with Hepatocellular Carcinoma (CHESS-NMCID 2101): A Multicenter Prospective Study
Xiaolong Qi[SUP] 1 [/SUP], Jitao Wang[SUP] 1 2 [/SUP], Qiran Zhang[SUP] 3 [/SUP], Jingwen Ai[SUP] 3 [/SUP], Chuan Liu[SUP] 1 [/SUP], Qianqian Li[SUP] 4 [/SUP], Ye Gu[SUP] 5 [/SUP], Jiaojian Lv[SUP] 6 [/SUP], Yifei Huang[SUP] 1 [/SUP], Yanna Liu[SUP] 7 [/SUP], Dan Xu[SUP] 1 [/SUP], Shubo Chen[SUP] 2 [/SUP], Dengxiang Liu[SUP] 2 [/SUP], Jinlong Li[SUP] 2 [/SUP], Huiling Xiang[SUP] 4 [/SUP], Jing Liang[SUP] 4 [/SUP], Li Bian[SUP] 5 [/SUP], Zhen Zhang[SUP] 5 [/SUP], Luxiang Liu[SUP] 7 [/SUP], Xuying Zhang[SUP] 8 [/SUP], Wei Qin[SUP] 9 [/SUP], Xiaodong Wang[SUP] 9 [/SUP], Zhiyun Hou[SUP] 10 [/SUP], Nina Zhang[SUP] 10 [/SUP], Aiguo Zhang[SUP] 10 [/SUP], Hongmei Zu[SUP] 11 [/SUP], Yun Wang[SUP] 11 [/SUP], Zhaolan Yan[SUP] 11 [/SUP], Du Xiufang[SUP] 12 [/SUP], Aifang Hou[SUP] 12 [/SUP], Jiansong Ji[SUP] 13 [/SUP], Jie Yang[SUP] 13 [/SUP], Jiansheng Huang[SUP] 13 [/SUP], Zhongwei Zhao[SUP] 13 [/SUP], Shengqiang Zou[SUP] 14 [/SUP], Hailei Ji[SUP] 14 [/SUP], Guohong Ge[SUP] 14 [/SUP], Qing-Lei Zeng[SUP] 15 [/SUP], Wenhong Zhang[SUP] 3 [/SUP]
Affiliations
- PMID: 35811309
- DOI: 10.1002/jmv.27992
Abstract
Data on safety and immunogenicity of coronavirus disease 2019 (COVID-19) vaccinations in hepatocellular carcinoma (HCC) patients are limited. In this multicenter prospective study, HCC patients received 2 doses of inactivated whole-virion COVID-19 vaccines. The safety and neutralizing antibody were monitored. Totally, 74 patients were enrolled from 10 centers in China, and 37 (50.0%), 25 (33.8%), and 12 (16.2%) received the CoronaVac, BBIBP-CorV, and WIBP-CorV, respectively. The vaccines were well tolerated, the injection site pain (6.8% [5/74]) and anorexia (2.7% [2/74]) were the most frequently local and systemic adverse events. The median level of neutralizing antibody was 13.5 (interquartile range [IQR]: 6.9-23.2) AU/mL at 45 (IQR: 19-72) days after the second dose of vaccinations, and 60.8% (45/74) of patients had positive neutralizing antibody. Additionally, lower gamma-glutamyl transpeptidase level was related to positive neutralizing antibody (odds ratio = 1.022 [1.003-1.049], p = 0.049). In conclusion, this study found that inactivated COVID-19 vaccinations are safe and the immunogenicity is acceptable or hyporesponsive in patients with HCC. Given that the potential benefits may outweigh the risks and the continuing emergences of novel severe acute respiratory syndrome coronavirus 2 variants, we suggest HCC patients to be vaccinated against COVID-19. Future validation studies are warranted. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus disease 2019; Hepatocellular carcinoma; Immunogenicity; Inactivated Vaccine; Safety..