tetano
Editor, Senior Moderator
J Med Virol
. 2021 Jan 28.
doi: 10.1002/jmv.26826. Online ahead of print.
Role of Toll-like receptors in the pathogenesis of COVID-19
Shaghayegh Khanmohammadi[SUP] 1 2 [/SUP], Nima Rezaei[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a pandemic since March 2020. The exact pathogenesis of SARS-CoV-2 and role of each component of innate and adaptive immune system is still unknown. However, available data from other corona virus families, such as SARS-CoV and Middle East respiratory syndrome (MERS) and also new findings could be useful for better understanding of SARS-CoV-2. Toll-like receptors (TLR) play an important role in recognition of viral particles and activation of innate immune system. Activation of TLR pathways lead to secretion of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-α, as well as type 1 interferon. Different TLRs, like TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, and TLR9 are potentially important in COVID-19 infection. It is also worth mentioning that we should not forget both beneficial and harmful effects of TLR in confronting COVID-19 infection. TLRs could be a potential target in controlling the infection in early stages of disease and production of vaccine against SARS-CoV-2. This article is protected by copyright. All rights reserved.
Keywords: Covid-19; Cytokines; SARS-CoV-2; Toll-like receptors.
. 2021 Jan 28.
doi: 10.1002/jmv.26826. Online ahead of print.
Role of Toll-like receptors in the pathogenesis of COVID-19
Shaghayegh Khanmohammadi[SUP] 1 2 [/SUP], Nima Rezaei[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 33506952
- DOI: 10.1002/jmv.26826
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a pandemic since March 2020. The exact pathogenesis of SARS-CoV-2 and role of each component of innate and adaptive immune system is still unknown. However, available data from other corona virus families, such as SARS-CoV and Middle East respiratory syndrome (MERS) and also new findings could be useful for better understanding of SARS-CoV-2. Toll-like receptors (TLR) play an important role in recognition of viral particles and activation of innate immune system. Activation of TLR pathways lead to secretion of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-α, as well as type 1 interferon. Different TLRs, like TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, and TLR9 are potentially important in COVID-19 infection. It is also worth mentioning that we should not forget both beneficial and harmful effects of TLR in confronting COVID-19 infection. TLRs could be a potential target in controlling the infection in early stages of disease and production of vaccine against SARS-CoV-2. This article is protected by copyright. All rights reserved.
Keywords: Covid-19; Cytokines; SARS-CoV-2; Toll-like receptors.